WO2006033826A1 - Fluid collection and testing device - Google Patents
Fluid collection and testing device Download PDFInfo
- Publication number
- WO2006033826A1 WO2006033826A1 PCT/US2005/031700 US2005031700W WO2006033826A1 WO 2006033826 A1 WO2006033826 A1 WO 2006033826A1 US 2005031700 W US2005031700 W US 2005031700W WO 2006033826 A1 WO2006033826 A1 WO 2006033826A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vial
- expresser
- fluid
- collection
- absorbent member
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/0003—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person
- A61B2010/0006—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person involving a colour change
Definitions
- the present invention generally relates to fluid specimen collection and testing devices and is more specifically directed to an oral fluid or saliva collection and testing devices.
- Sampling and testing of body fluids is common for both testing and monitoring the human body for any number of biochemical or physiological conditions and, of course, for determining the general state of health of an individual.
- saliva as a testing medium is often preferable due to its availability without intrusive methods such as is required in sampling of blood.
- Urine samples although non invasive, require patient monitoring during sampling to insure integrity. Accordingly, the use of saliva as a medium in biochemical and physiological analysis is desirable since it can be obtained by non-invasive methods and is easily monitored.
- saliva has been found to be a very reliable carrier of analyte indicators and lateral flow chromatographic immunoassays which are useful for the qualitative detection of amphetamines, methamphetamine, cocaine, opiates, THC and their metabolites and other drugs of misuse and substances along with applications including nucleic acid markers and viral infections such as HIV.
- the present invention is directed to a fluid collection and testing device which facilitates a separation of saliva from a collector and enables drip-free and easy isolation of the saliva specimen in a container.
- a fluid collection and testing device in accordance with the present invention generally includes a collection vial having a bottom and an open top.
- An expresser is provided and sized for insertion into the vial open end with the expresser having a ribbed base for enabling fluid to pass therethrough.
- a support member is provided for holding the expresser within the collector vial with the ribbed base in a spaced apart relationship with the vial bottom. In this manner, separate tim ⁇ , sucn as sanva, is collected in the vial, which is isolated from the expresser after separation from a fluid collector.
- a fluid collector in accordance with the present invention includes an absorbent member for capturing a fluid with the absorbent member being sized for insertion into the expresser and compressible against the ribbed base for releasing captured fluid therein through the ribbed base and into the vial bottom.
- a catch mechanism is provided for latching the fluid collector to the expresser after insertion into the expresser and this enables the removal of the expresser from the collection vial with the fluid collector. This significantly reduces the possibility of contact or exposure of the saliva after expressing.
- a fluid test card may be provided and sized for insertion into the collection vial and includes test strips for wicking fluid from the vial bottom.
- the collection vial is cylindrical and the vial bottom has a conical shape for accumulation of fluid and centering of the test card therein.
- the test card may include a bottom, which is shaped for conforming to and nesting in the conical shape of the collection vial bottom.
- the collection vial may be a triangular tube and the vial bottom may be slanted toward a side of the tube and include a trough for accumulation of fluid and receiving a test card bottom.
- the device in accordance with the present invention may include crush ribs disposed on a circumference of the expresser for providing an interference fit with an inside circumference of the collection vial. This structure is provided to both stabilize the expresser within the collection vial and to prevent premature removal of the expresser from the collection vial.
- the support member hereinabove noted may include an outwardly extending flange for engaging the vial top in order to suspend the expresser within the collection vial with the ribbed base in a spaced apart relationship with the vial bottom, as hereinabove noted.
- the fluid collector includes a handle and a stem interconnecting the absorbent member and the handle and the catch mechanism includes a skirt radially extending from the stem and a ring disposed on inner circumference of the expresser for latching the skirt.
- the skirt is pushed past the ring during expressing of saliva from the absorbent member and withdrawal of the fluid collector, now latched, or attached, to the expresser, removes the expresser simultaneously therewith from the collection vial.
- the fluid collector further includes a second skirt adjacent the absorbent member causing compression of the absorbent member against the ribbed base upon movement of the inserted fluid collector toward the vial bottom.
- the absorbent member is sized for enabling expansion, after compression, in order to both force the skirt against the ring to provide a positive latch and to cause absorption of any surface fluid on the absorbent member caused by compression. This eliminates dripping of fluid during withdrawal of the collection and expresser from the vial.
- the expresser may be provided with a tapered sidewall portion.
- a method in accordance with the present invention for a collection of fluid generally • includes providing a collection vial and inserting an expresser thereinto. The method further includes capturing a fluid in an absorbent member attached to a fluid collector and inserting the absorbent member into the expresser with the fluid collector.
- the absorbent member is compressed within the expresser to release captured fluid into the vial.
- the method further includes latching the fluid collector to the expresser and thereafter removing the latched fluid collector and expresser from the vial without dripping.
- a test card may thereafter be inserted into the vial for performing analysis in the fluid and the vial may be capped for storage of the fluid or for subsequent testing or disposal.
- Figure 1 is an exploded perspective view of a fluid collection and testing device in accordance with the present invention generally showing a collection vial, an expresser along with a fluid collector including an absorbent member for capturing a fluid;
- Figure 2 is a cross section view of the expresser shown in Figure 1 and taken along the line 2-2 and showing a ribbed base;
- Figure 3 is a cross sectional view of the device shown in Figure 1 showing the expresser inserted into the collection vial and supported therein with the ribbed base in a spaced apart relationship with a vial bottom along with the absorbent member being introduced into the expresser by the fluid collector;
- Figure 4 is another cross sectional view illustrating full insertion of the absorbent member into the expresser and compression thereof by the fluid collector against the expresser ribbed base and latching of the fluid collector to the expresser as will be hereinafter described in greater detail;
- Figure 5 is still another cross sectional view illustrating the simultaneous removal of the fluid collector and expresser from the vial
- Figure 6 shows a fluid test card inserted into the collection vial with test strips for wicking fluid from the vial bottom along with a cap fitted to an open top of the collection vial;
- Figure 7 is an alternative embodiment of the present invention generally illustrating a triangular fluid collection vial along with an expresser and a fluid collector with an absorbent member;
- Figure 8 is a cross sectional view of the embodiment shown in Figure 7 illustrating compression of the absorbent member and latching of the fluid collector to the expresser; and Figure 9 is a cross sectional view illustrating a fluid test card inserted into the collection vial with test strips for wicking fluid from the vial bottom.
- a fluid collection and testing device 10 in accordance with the present invention generally including a cylindrical collection vial 14 having a bottom 16 and an open top 18 along with an expresser 22 sized for insertion into the vial open top 18, as illustrated in Figures 3-4.
- the expresser 22 includes a ribbed base 26 for enabling fluid to pass therethrough and a support member, such as a flange 30, outwardly extending for engaging the vial top 18, as illustrated in Figures 3-4.
- vial 14 and expresser 22 as well as all of other components of the present invention may be formed from conventional suitable materials such as plastics and the like.
- the ribbed base 26 may include a plurality of radial ribs 34, although other rib patterns may be suitable for enabling passage of fluid therethrough.
- the support member, or flange, 30 holds the expresser 22 within the collection vial 14 with the ribbed base 26 in a spaced apart relationship with the vial bottom 16.
- Other support members may be utilized in accordance with the present invention.
- me expresser 22 may include a tapered sidewall portion 38 for facilitating insertion of the expresser 22 into the collection vial 14.
- a narrowed portion 40 of the expresser 22 is disposed in a spaced apart relationship with an inner circumference 44 of the collection vial 14.
- a fluid collector 48 including an absorbent member 52, handle 54, and inner connecting stem 56 is provided for accumulating a sample from a patient's mouth, not shown.
- the absorbent member 52 which may be a foam or sponge-like material, is sized for insertion into the expresser 22, see Figures 3-4, and compressible against the ribbed base 26, see Figure 4, for releasing captured fluid through the ribbed base 26 and into the vial bottom 16.
- a skirt 60 extending radially from the stem 56.
- member 52 compresses and releases, or expresses captured fluid 68, as also shown in Figure 4.
- a catch mechanism 72 is provided for latching the fluid collector 48 to the expresser 22 after insertion of the fluid collector 48 into the expresser 22. This latching enables the removal of the expresser from the collection vial 14 simultaneously with the fluid collector 48 and thus subsequent touching or handling of the expresser 22 now exposed to saliva is not necessary.
- the catch mechanism 72 may include in combination, a skirt 78 radially extending from the collector stem 56 and a ring 80 disposed on an inner circumference 82 of the expresser 22, see also Figure 2.
- the skirt 78 has a diameter greater than a diameter of the expresser measured within the ring 80 and accordingly once the skirt 78 is forced passed the ring 80 during compression of the absorbent member 52 (see Figure 4), removal of the collector 48 from the vial 14 lifts the expresser 22 simultaneously with the collector 48 from the vial 14, as shown in Figure 5.
- the absorbent member 52 is sized, i.e. has a length, for permitting expansion subsequent to compression. This subsequent expansion forces the skirt 78 against the ring 80 while at the same time reabsorbs any fluid forced to a surface 52A of the member 52 during compression. This reabsorption eliminates, or significantly reduces, the possibility of fluid dripping during withdrawal of the collector 48 and expresser 22 from the vial 14. This, of course, reduces the possibility of contaminating adjacent surfaces (not shown).
- crush ribs 86 may be provided on a circumference 88 of the expresser 22 tor providing an interference fit with the inner circumference 44 of the collection vial 14, see Figure 1 and 2.
- a fluid test card 92 may be inserted into the collection vial 14, see Figure 6.
- the card 92 may be a conventional lateral flow chromatographic immunoassay device having test strips 94 with bottom inlets 96 for wicking fluid from the vial bottom 16.
- a card bottom 100 may have a generally arcuate, or triangular shape 102 for conforming to the vial bottom 16 which has a conical shape 104 for accumulation of fluid 110 and centering of the test card 92, as illustrated in Figure 6. Operation of the device 10 is illustrated in Figures 3 - 6.
- the expresser 22 is first inserted into the vial 14 with the crush ribs 86 providing a snug fit therein.
- the collector 48 and expresser 22 are simultaneously removed from the vial 14 due to latching between the collector 48 and expresser 22 by the catch mechanism 72 which includes the skirt 78 and ring 80. Expansion of the absorbent member 52 after compression, as hereinabove noted, prevents dripping of fluid.
- test card 92 may then be inserted into the vial 14 for sufficient period of time to wick fluid 110 from the bottom 16 of the vial 14. After wicking, the card 92 may be removed from the vial or left in the vial 14 which may be sealed with a cap 106 in a conventional manner for preserving remaining fluid 110 in the vial bottom 16 for subsequent testing or disposal ( Figure 6).
- a collection vial 116 comprises a triangular tube as best shown in Figure 7.
- An expresser 122 includes a circular chimney 124 with a triangular flange 126 for engaging a vial wall step 128.
- the vial 116 includes a vial bottom 130 slanted toward a side 132 of the vial 116 and includes a trough 134 far ar.r.nm ⁇ 1atinn of fluid and receiving a test card 136.
- test card I J b is similar to me car ⁇ y2 except, as shown in Figure 6, includes a flat bottom 130 for nesting in the trough 134.
- the flange 78 engages a ring 140 for latching the collector 48 to the expresser 122 to enable simultaneous removal from the vial.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007003138A MX2007003138A (en) | 2004-09-16 | 2005-09-02 | Fluid collection and testing device. |
AU2005287246A AU2005287246B2 (en) | 2004-09-16 | 2005-09-02 | Fluid collection and testing device |
EP05794361A EP1788951A1 (en) | 2004-09-16 | 2005-09-02 | Fluid collection and testing device |
CA2579183A CA2579183C (en) | 2004-09-16 | 2005-09-02 | Fluid collection and testing device |
JP2007532368A JP2008513777A (en) | 2004-09-16 | 2005-09-02 | Fluid sampling and testing equipment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/942,493 US7282181B2 (en) | 2004-09-16 | 2004-09-16 | Fluid collection and testing device |
US10/942,493 | 2004-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006033826A1 true WO2006033826A1 (en) | 2006-03-30 |
Family
ID=35447638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/031700 WO2006033826A1 (en) | 2004-09-16 | 2005-09-02 | Fluid collection and testing device |
Country Status (7)
Country | Link |
---|---|
US (1) | US7282181B2 (en) |
EP (1) | EP1788951A1 (en) |
JP (1) | JP2008513777A (en) |
AU (1) | AU2005287246B2 (en) |
CA (1) | CA2579183C (en) |
MX (1) | MX2007003138A (en) |
WO (1) | WO2006033826A1 (en) |
Cited By (2)
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JP2010525330A (en) * | 2007-04-16 | 2010-07-22 | オラシュアテクノロジーズ, インコーポレイテッド | Sample collector |
DE102009010563A1 (en) * | 2009-02-16 | 2010-08-26 | Matthias W. Engel | Device for the detection of analytes in body fluids |
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US7879293B2 (en) * | 2001-09-28 | 2011-02-01 | Orasure Technologies, Inc. | Sample collector and test device |
US7927548B2 (en) * | 2005-01-27 | 2011-04-19 | Bamburgh Marsh Llc | Specimen sample collection device and test system |
US7915032B2 (en) * | 2006-03-03 | 2011-03-29 | Capitol Vial Inc. | Sample collection system and method |
US7749772B1 (en) | 2006-06-29 | 2010-07-06 | Varian, Inc. | Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol |
US8517728B2 (en) | 2007-01-24 | 2013-08-27 | Colgate-Palmolive Company | Oral care implement having fluid delivery system |
US7981054B2 (en) * | 2007-07-16 | 2011-07-19 | Phuong Nguyen | All-in-one biological specimen collecting, transporting and analyzing device |
US7749383B2 (en) * | 2007-09-06 | 2010-07-06 | Cummins Filtration Ip, Inc. | Filter cartridge with crush ribs |
US20090143699A1 (en) * | 2007-11-29 | 2009-06-04 | John Wu | Fluid sample collecting and analyzing apparatus |
US7854895B2 (en) * | 2008-02-13 | 2010-12-21 | Capitol Vial Inc. | Fluid sample collection system and method |
US7850922B2 (en) * | 2008-02-13 | 2010-12-14 | Capitol Vial Inc. | Fluid sample collection system |
US20090269247A1 (en) | 2008-04-29 | 2009-10-29 | Robert Lee Grenz | Fluid collection device with expresser plug holder |
US8105549B2 (en) * | 2008-11-19 | 2012-01-31 | Sun Biomedical Laboratories, Inc | Sample collection device |
JP5833450B2 (en) | 2008-12-31 | 2015-12-16 | スリーエム イノベイティブ プロパティズ カンパニー | Detection method of living bioburden using microparticles |
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AU2009341554B2 (en) * | 2009-03-04 | 2015-07-09 | Siyu Lei | Collection and assay device for biological fluid |
WO2010118067A1 (en) * | 2009-04-06 | 2010-10-14 | Oasis Diagnostics Corporation | Apparatus for generating and collecting saliva samples containing enhanced cell concentrations |
US8202230B2 (en) | 2009-08-20 | 2012-06-19 | Colgate-Palmolive Company | Oral care implement having a liquid collection system |
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US9284593B2 (en) | 2009-12-30 | 2016-03-15 | 3M Innovative Properties Company | Live bioload detection using microparticles |
US9113850B2 (en) | 2010-08-20 | 2015-08-25 | Reflex Medical Corp. | Saliva collection device |
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GB2500658A (en) * | 2012-03-28 | 2013-10-02 | Dna Electronics Ltd | Biosensor device and system |
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WO2014163588A1 (en) * | 2013-04-05 | 2014-10-09 | Nitto Denko Corporation | Device for collection of a fluid sample, receptacle for receiving the device, an assembly for collection of a fluid sample, and a method of collecting a fluid sample |
US10035146B2 (en) * | 2013-05-24 | 2018-07-31 | Premier Biotech, Inc. | Multi-stage oral-fluid testing device |
USD770636S1 (en) * | 2014-09-17 | 2016-11-01 | Assure Tech.(Hangzhou) Co., Ltd. | Detection device for medical purposes |
USD836209S1 (en) * | 2015-01-16 | 2018-12-18 | Assure Tech. (Hangzhou) Co., Ltd. | Detection device for medical purposes |
US20160074018A1 (en) * | 2015-11-23 | 2016-03-17 | Michelle Marie Lependorf | Urine Specimen Collection Kit With Retractable/Adjustable Handle and Sponge |
DE102016012369B3 (en) * | 2016-10-15 | 2017-02-23 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium der Verteidigung, vertreten durch das Bundesamt für Ausrüstung, Informationstechnik und Nutzung der Bundeswehr | Sampling kit for a CBRN sample |
WO2020049569A2 (en) | 2018-09-05 | 2020-03-12 | Hero Scientific Ltd. | Testing for particulates |
GB201703383D0 (en) | 2017-03-02 | 2017-04-19 | Gargle Tech Ltd | Testing for particulates |
CN107036847A (en) | 2017-04-13 | 2017-08-11 | 杭州旭科生物技术有限公司 | A kind of applicator |
CN110338849A (en) * | 2018-04-08 | 2019-10-18 | 迈博高分子材料(宁波)有限公司 | A kind of saliva collecting device |
KR102210167B1 (en) * | 2018-12-27 | 2021-02-01 | 주식회사 노블바이오 | Sampling tool for animal |
US11724255B2 (en) * | 2019-02-14 | 2023-08-15 | Marshall Venture Partners LLC | Systems and methods for fluid sample collection and testing |
US11730458B2 (en) * | 2019-02-14 | 2023-08-22 | Marshall Venture Partners LLC | Systems and methods for fluid sample collection and testing |
US20230338012A1 (en) * | 2020-02-05 | 2023-10-26 | Marshall Venture Partners LLC | Systems and Methods for Fluid Sample Collection and Testing |
JP6931839B1 (en) * | 2020-08-07 | 2021-09-08 | 株式会社臨床検査器材 | Specimen collection kit |
CA3189431A1 (en) | 2020-08-28 | 2022-03-03 | Avi ROBBINS | Liquid collection device |
EP4165385B1 (en) | 2021-01-06 | 2024-04-17 | Hero Scientific Ltd | Filtration sampling devices |
USD971432S1 (en) * | 2021-03-23 | 2022-11-29 | Bayer Consumer Care Ag | Diagnostic device component |
DE102021115185A1 (en) | 2021-06-11 | 2022-12-15 | Universität Heidelberg Körperschaft des öffentlichen Rechts | Sampling system for taking a saliva sample yourself |
IT202100017780A1 (en) * | 2021-07-06 | 2023-01-06 | Univ Degli Studi Padova | DEVICE AND PROCEDURE FOR THE COLLECTION AND MANIPULATION OF A SALIVARY SAMPLE |
GB2611509A (en) * | 2021-08-02 | 2023-04-12 | Conceptomed As | Sample collection devices |
KR102356273B1 (en) * | 2021-08-11 | 2022-02-08 | 김민정 | Urine collection tube |
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2004
- 2004-09-16 US US10/942,493 patent/US7282181B2/en not_active Expired - Fee Related
-
2005
- 2005-09-02 AU AU2005287246A patent/AU2005287246B2/en not_active Ceased
- 2005-09-02 EP EP05794361A patent/EP1788951A1/en not_active Withdrawn
- 2005-09-02 JP JP2007532368A patent/JP2008513777A/en not_active Ceased
- 2005-09-02 MX MX2007003138A patent/MX2007003138A/en not_active Application Discontinuation
- 2005-09-02 WO PCT/US2005/031700 patent/WO2006033826A1/en active Application Filing
- 2005-09-02 CA CA2579183A patent/CA2579183C/en not_active Expired - Fee Related
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EP0250170A2 (en) * | 1986-06-16 | 1987-12-23 | Evergreen Industries Inc. | Specimen collector |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010525330A (en) * | 2007-04-16 | 2010-07-22 | オラシュアテクノロジーズ, インコーポレイテッド | Sample collector |
DE102009010563A1 (en) * | 2009-02-16 | 2010-08-26 | Matthias W. Engel | Device for the detection of analytes in body fluids |
US9414813B2 (en) | 2009-02-16 | 2016-08-16 | Express Diagnostics Int'l, Inc. | Device for assaying analytes in bodily fluids |
US9462998B2 (en) | 2009-02-16 | 2016-10-11 | Express Diagnostics Int'l, Inc. | Device for assaying analytes in bodily fluids |
US10076314B2 (en) | 2009-02-16 | 2018-09-18 | Express Diagnostics Int'l, Inc. | Device for assaying analytes in bodily fluids |
Also Published As
Publication number | Publication date |
---|---|
EP1788951A1 (en) | 2007-05-30 |
AU2005287246A1 (en) | 2006-03-30 |
CA2579183A1 (en) | 2006-03-30 |
US20060057027A1 (en) | 2006-03-16 |
AU2005287246B2 (en) | 2010-04-29 |
CA2579183C (en) | 2010-11-02 |
JP2008513777A (en) | 2008-05-01 |
US7282181B2 (en) | 2007-10-16 |
MX2007003138A (en) | 2007-05-23 |
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