WO2006042582A1

WO2006042582A1 - Teeth-polishing mouth and tooth care and cleaning substances that reduce bad breath

Info

Publication number: WO2006042582A1
Application number: PCT/EP2005/009364
Authority: WO
Inventors: Ullrich Bernecker; Adolf Peter Barth; Wilfried Howorka
Original assignee: Henkel Kommanditgesellschaft Auf Aktien
Priority date: 2004-10-18
Filing date: 2005-08-31
Publication date: 2006-04-27
Also published as: DE102004050954A1; EP1802374A1

Abstract

Disclosed are mouth and tooth care and cleaning substances which polish and clean the tooth surface well without having an overly abrasive effect while acting against bad breath. Said substances contain at least 10 percent by weight of sorbit and/or glycerin and/or 1,2-propylene glycol as well as at least 0.25 percent by weight of at least one bioactive glass.

Description

HENKEL KGaA Semrau / yes 18.10.2004

"Tooth-smoothing and malodour-reducing oral and dental care and cleaning agents"

The invention relates to preparations for oral and dental care and cleaning, which act tooth smoothing due to special ingredients, have a high cleaning performance, without scratching the tooth surface or to be very abrasive and beyond the Disease of halitosis and reduce bad breath.

Dentifrices are in various forms on the market and serve primarily the cleaning of the tooth surface and the prevention of dental and Zahn¬ meat diseases. They usually contain a combination of polishing agents, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents. In addition to toothpowder, which play a minor role because of their increased abrasiveness, dentifrices are mainly offered in paste, cream and translucent or transparent gel form. Liquid or liquid toothpastes and mouthwashes have also become increasingly important in recent years.

In addition to the cleaning of the teeth, the consumer of the generic products also expected a care of the teeth and the oral cavity. In particular, a "clean" feel, ie a smooth and shiny tooth surface as well as a fresh mouthfeel are essential aspects for the buying incentive of oral and dental care and cleaning preparations. A successful remedy of the generic type should therefore thoroughly clean the teeth without damaging the tooth or tooth surface while reducing and / or preventing bad breath. Antimicrobial glasses are known in the art. For example, US Pat. No. 5,290,544 describes water-soluble glasses for use in cosmetic products with very low SiO ₂ and very high B ₂ O ₃ or high P ₂ O ₅ contents. The glasses have silver concentrations greater than 0.5 wt .-%. These glasses have extremely low hydrolytic resistance and tend to dissolve completely in water. The released Ag and / or Cu ions have an antibacterial effect. No. 6,143,318 describes silver-containing phosphate glasses which are used as antimicrobial material for wound infection treatment with combinations of Cu, Ag and Zn. These are also water-soluble glasses which have low SiO ₂ concentrations and very high P ₂ O ₅ contents.

The present invention has for its object to provide preparations for oral and dental care and cleaning, combine the advantages in terms of cleaning performance with low abrasiveness and reduced scratching of the tooth surface. In addition, the products should smooth the tooth surface and counteract bad breath.

It has now been found that the use of certain antimicrobial glasses in combination with sorbitol or glycerol or 1, 2-propylene glycol or mixtures of these substances in preparations for oral and dental care and cleaning has the required properties and in particular tooth smoothing properties and has Halitosis prevents or reduces.

The present invention relates in a first embodiment to oral and dental care and cleaning compositions comprising a) at least 10% by weight of sorbitol and / or glycerol and / or 1,2-propylene glycol; b) at least 0.25% by weight of at least one bioactive glass.

Oral and dental care products as well as mouth and tooth cleaning agents in the sense of the invention are mouthwashes and toothpowder, oral and toothpastes, liquid mouthwashes and toothpastes as well as oral and dental gels. Preferably, toothpastes and liquid dentifrices are suitable. For this purpose, the oral and dental care and cleaning agents, for example in the form of toothpastes, liquid toothpastes, tooth powders, mouthwashes or possibly also as gum, z. B. as chewing gum, present. Preferably, however, they are present as more or less flowable or plastic toothpastes, as they are used for cleaning the teeth using a toothbrush.

The compositions of the invention contain as the first essential ingredient at least 10 wt .-% sorbitol and / or glycerol and / or 1, 2-propylene glycol, which - unless expressly stated otherwise - all wt .-% - information in the context of the present invention refer to the entire preparation.

Sorbitol (also referred to as glucitol) is a sugar alcohol of glucose, ie, a hexitol sorbitol can be prepared by hydrogenation of glucose, is intramolecularly relatively easy to split-one or two molecules of water, and forms cyclic ethers

CH ₂ OH

HO-C-H H-C-OH H-C-OH

CH ₂ OH

describe and comes in the form of colorless, moderately hygroscopic, optically active needles, which dissolve easily in water, in the trade.

Glycerol (1,2,3-propanetriol, 1,2,3-trihydroxypropane, glycerol, oil sweet, INCI name: Glycerin, E 422) is a colorless, clear, heavy-bodied, odorless, sweet-tasting, hygroscopic liquid that combines with water and alcohol is miscible in any ratio.

Glycerol can be defined by the formula

H ₂ C-OH

HC OH

H ₂ C-OH

describe. The production of glycerol was originally as a by-product of fat saponification. Today's technical processes are based on propene, which is processed via the intermediates allyl chloride and epichlorohydrin to glycerol. Another one technical process is the hydroxylation of allyl alcohol with hydrogen peroxide at the WO ₃ contact via the step of the glycide.

1, 2-Propylene glycol (1, 2-propanediol) is a colorless and highly hygroscopic liquid which is miscible in any ratio with water and alcohols (such as methanol, ethanol, propanols, butanols). Technical 1,2-propanediol is a racemate of (-) - (R) - and (+) - (S) -1, 2-propylene glycol. The preparation is carried out by direct hydrolysis of propylene oxide. Because 1, 2-P. further reacted with propylene oxide, thereby forming a mixture of 1, 2 and tripropylene glycol, which must be separated by distillation. 1,2-propylene glycol can also be made from renewable resources via three different routes: a) catalytic hydrogenation of sugars; b) fermentation of sugars to lactic acid and then hydrogenation of the lactic acid ester; c) direct fermentation of sugars.

Particularly preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain from 12 to 60% by weight, preferably from 15 to 50% by weight, particularly preferably from 17 to 40% by weight and in particular from 20 to 35% by weight. -% sorbitol and / or glycerol and / or 1, 2-propylene glycol.

For certain applications, it may be advantageous to use only one of the three ingredients mentioned above. In most cases, sorbitol is preferred. However, in other applications, mixtures of two of the three or all three may be preferred. Here, a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1): (0.1-0.5) has proved particularly advantageous.

As a second essential ingredient, the compositions according to the invention contain at least 0.25% by weight of at least one bioactive glass.

In the context of the present application, the term "bioactive glasses" encompasses glasses which are biologically active and / or biologically active The biological effectiveness of a glass can be demonstrated in its antimicrobial properties, for example, biologically active glass differs from conventional lime-sodium silicate - Glass by bonding living tissue, for example, a glass that forms a firm bond with body tissue, forming a hydroxyapatite layer, or a glass under bioactive glass understood that shows antimicrobial and / or anti-inflammatory activity. The glass powders show a biocidal or biostatic effect against bacteria, fungi and viruses; are in contact with humans skin-friendly, toxicologically safe and especially suitable for consumption.

The oral and dental care and cleaning compositions of the invention contain bioactive glass or glass powder or glass ceramic powder or composite materials comprising such a bioactive glass. For the purposes of the present application, glass powders are also understood as meaning granules and glass beads.

According to the invention, at least 0.25% by weight of at least one bioactive glass is contained in the oral and dental care and cleaning compositions. Preferred oral and dental care and cleaning agents according to the invention are characterized in that they contain from 0.2 to 20% by weight, preferably from 0.4 to 14% by weight, particularly preferably from 0.5 to 3% by weight and in particular 0.6 to 2 wt .-% of at least one bioactive glass.

Due to the requirements for the toxicological safety of the glass and its suitability for consumption, the glass powder should be particularly pure. The burden of heavy metals is preferably low. Thus, the maximum concentration in the range of cosmetic formulations is preferably for Pb <20 ppm, Cd <5 ppm, As <5 ppm, Sb <10 ppm, Hg <1 ppm, Ni <10 ppm.

The unfused starting glass, which is directly contained in the compositions according to the invention or is optionally used for the production of a glass ceramic which can be used according to the invention, contains SiO ₂ as a network former, preferably between 35-80% by weight. At lower concentrations, the spontaneous tendency to crystallize increases greatly and the chemical resistance decreases sharply. At higher SiO ₂ values, the crystallization stability may decrease and the processing temperature is significantly increased, so that the hot-forming properties deteriorate. Na ₂ O is used as a flux when melting the glass. At concentrations of less than 5%, the melting behavior is adversely affected. Sodium is part of the at the Ceramization forming phases and, if high crystalline phase proportions are to be set by the ceramization, must be contained in correspondingly high concentrations in the glass. K ₂ O acts as a flux when melting the glass. In addition, potassium is released in aqueous systems. If high potassium concentrations are present in the glass, potassium-containing phases such as calcium silicates are also eliminated. The P ₂ O ₅ content of silicate glasses, glass ceramics or composites can be used to adjust the chemical resistance of the glass and thus the release of ions in aqueous media. For Phospaht glasses, P ₂ O _{5 is} network images. The P ₂ O ₅ content is preferably between 0 and 80 wt .-%. In order to improve the meltability, the glass may contain up to 25% by weight of B ₂ O ₃ . Al ₂ O ₃ is used to adjust the chemical resistance of the glass.

To enhance the antimicrobial, in particular the antibacterial properties of the glass-ceramic antimicrobial acting ions such. B. Ag, Au, I, Ce, Cu, Zn in concentrations less than 5 wt .-% may be included.

Coloring ions such. As Mn, Cu, Fe, Cr, Co, V, may be contained individually or in combination, preferably in a total concentration less than 1 wt .-%.

Usually, the glass or the glass ceramic is used in powder form. The ceramization can be done either with a glass block or Glasribbons or with glass powder. After ceramization, the glass ceramic blocks or ribbons must be ground to powder. If the powder has been ceramified, it may also be necessary to re-mill to remove agglomerates formed during the ceramification step. The grinding can be carried out both dry and in aqueous or non-aqueous grinding media. Usually, the particle sizes are less than 500 microns. As appropriate, particle sizes <100 microns or <20 microns have been found. Particularly suitable are particle sizes <10 microns and less than 5 microns and less than 2 microns, see below.

The bioactive glasses or glass powder or glass ceramic powder or composite compositions contained in the compositions according to the invention comprise glasses which preferably comprise the following components: SiO ₂ : 35-80% by weight, Na ₂ O: 0-35% by weight, P ₂ O ₅ : 0-80% by weight, MgO: 0-5% by weight, Ag ₂ O: 0-0.5% by weight, AgJ: 0-0.5% by weight, NaI: 0-5 wt.%, TiO ₂ : 0-5 wt.%, K ₂ O: 0-35 wt.%, ZnO: 0-10 wt.%, Al ₂ O ₃ : 0-25 wt % and B ₂ O ₃ : 0-25% by weight.

- i Furthermore, the base glass according to the above composition to achieve further effects such as color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10 wt .-%. A further glass composition may be as follows: SiO ₂ : 35-80 wt%, Na ₂ O: 0-35 wt%, P ₂ O ₅ : 0-80 wt%, MgO: 0-5 wt %, Ag ₂ O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ: 0-5 wt%, TiO ₂ : 0-5 wt% , K ₂ O: 0-35 wt .-%, ZnO: 0-10 wt .-%, Al ₂ O ₃ : 0-25 wt .-%, B ₂ O ₃ : 0- 25 wt .-%, SnO : 0-5 wt%, CeO ₂ : 0-3 wt% and Au: 0.001-0.1 wt%.

Particularly preferred oral and dental care and cleaning agents according to the invention are characterized in that the bioactive glass - based on its weight - has the following composition:

SiO ₂ 35 to 60% by weight, preferably 40 to 60% by weight,

Na ₂ O 0 to 35 wt .-%, preferably 5 to 30 wt .-%,

K ₂ O 0 to 35 wt .-%, preferably 0 to 20 wt .-%,

P ₂ O ₅ O to 10 wt .-%, preferably 2 to 10 wt .-%,

MgO 0 to 10% by weight, preferably 0 to 5% by weight,

CaO 0 to 35% by weight, preferably 5 to 30% by weight,

Al ₂ O ₃ 0 to 25 wt .-%, preferably 0 to 5 wt .-%,

B ₂ O ₃ 0 to 25 wt .-%, preferably 0 to 5 wt .-%,

TiO ₂ O to 10 wt .-%, preferably 0.1 to 5 wt .-%.

As already mentioned above, the bioactive glass is preferably used in particulate form. Here are particularly preferred oral and dental care and cleaning agent according to the invention characterized in that the antimicrobial glass particle sizes <10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns having.

The oral and dental care and cleaning compositions according to the invention may contain, in addition to the aforementioned essential ingredients, other ingredients of oral cleansers, oral hygiene products, dentifrices and / or dentifrices. The preferred further ingredients are described below.

The oral and dental care and cleaning agents according to the invention, in particular the toothpastes, z. B. antimicrobial substances as preservatives or as Contain antiplaque agents. Such substances may, for. B. be selected from p-Hydroxybenzoesäuremethyl-, ethyl or propyl, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylates, biguanides z. For example, chlorhexidine, thymol, etc. According to preferred oral and dental care and - cleaning agents are characterized in that they additionally antiplaque agents, preferably p-Hydroxybenzoesäuremethyl-, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl Salicylic acid esters, biguanides z. As chlorhexidine, thymol, preferably in amounts of 0.1 to 5 wt.%, Preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1, 5 wt.%, Each based on the total Means, included.

Another preferred group of ingredients that may be included in the compositions of the invention are the anti-caries agents. These may be selected, for example, from organic or inorganic fluorides, for. Example of sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, stannous fluoride are preferred. An amount of 0.01-0.2% by weight of fluorine should preferably be present in the form of the compounds mentioned.

Oral and dental care and cleaning compositions according to the invention, which additionally anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate, preferably in amounts of 0.01 to 5 wt.%, Preferably from 0.1 to 2.5 wt.% And in particular from 0.2 to 1, 1 wt.%, Each based on the total agent, are preferred according to the invention.

The oral and dental care and cleaning agents, in particular the toothpastes, for example, may also contain substances that are effective against tartar. Such substances may be, for example, chelating agents such. As ethylenediaminetetraacetic acid and its sodium salts, pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. B. Na ₄ P ₂ O ₇ , K ₄ P ₂ O ₇ , Na ₂ K ₂ P ₂ O ₇ , Na ₂ H ₂ P ₂ O ₇ and K ₂ H ₂ P ₂ O ₇ or polyphosphate salts, the z. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected. In accordance with the invention preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.

The compositions according to the invention, in particular toothpastes or liquid toothpastes, preferably contain one or more polishing agents, usually in an amount of from 5 to 50% by weight.

As a polishing agent are in principle all known for toothpastes friction body, in particular those that do not contain calcium ions. Preferably suitable polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such friction bodies.

Calcium containing polishing components such as e.g. However, chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can be present in amounts of up to 5% by weight.

The total content of polishing agents is preferably in the range of 5 to 50% by weight of the dentifrice.

Particular preference is given to toothpastes and liquid dentifrices which contain silicic acids as polishing agents. Suitable silicas are e.g. Gel silicas, hydrogel silicas and precipitated silicas. Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying is carried out under mild conditions to a water content of 15 to 35 wt .-%, the so-called hydrogel silicic acids are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.

A second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods for preferably suitably a precipitated silica having a BET surface area of 15 - 110 m2 / g, a particle size of 0.5-20 microns, wherein at least 80 wt .-% of the primary particles should be below 5 microns, and a viscosity in 30% glycerol water (1: 1) dispersion of 30 - 60 Pa. s (20 ⁰ C) in an amount of 10 to 20 wt .-% of the toothpaste. Preferred precipitated silicas of this type also have rounded corners and edges and are available under the trade name Sident12 DS (DEGUSSA).

Other precipitated silicas of this type are Sident 8 (DEGUSSA) and Sorbosil AC 39 (Crosfield Chemicals). These silicas are characterized by a lower thickening effect and a slightly higher average particle size of 8-14 microns with a specific surface area of 40-75 m2 / g (according to BET) and are particularly well suited for liquid toothpastes. These should have a viscosity (25 ° C, shear rate D = 10 s-1) of 10 - 100 Pa.s.

Toothpastes, which have a significantly higher viscosity of more than 100 Pa.s (25 ° C, D = 10 s-1), however, require a sufficiently high proportion of silicas having a particle size of less than 5 microns, preferably at least 3 wt. -% of a silica with a particle size of 1 - 3 microns. To such toothpastes, it is therefore preferable to add finely divided, so-called thickened silicas having a BET surface area of 150-250 m 2 / g, in addition to the precipitated silicas mentioned, for example. the commercial products Sipernat 22 LS or Sipemat 320 DS.

As a further polishing agent component, e.g. Aluminum oxide in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-%. Such a suitable alumina is available under the trade designation "Polianton earth P10 finest" (Giulini Chemie).

As a polishing agent are all further known for toothpastes friction body such. B. sodium aluminum silicates such. As zeolite A, organic polymers such. As polymethacrylate or mixtures of these and the aforementioned friction body.

In summary, oral and dental care and cleansing compositions according to the invention are preferred which additionally have cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ .2H ₂ O), sodium aluminum silicates, in particular zeolite A, organic Polymers, in particular polymethacrylates or mixtures of these Reibkörper.vorzugsweise preferably in amounts of 1 to 30 wt.%, Preferably from 2.5 to 25 wt.% And in particular from 5 to 20 wt.%, Each based on the total agent.

As a carrier for the toothpastes, which allows the setting of a suitable consistency for the dosage from tubes, dispensing containers or flexible bottles, is for example a combination of humectants, binders and water.

Humectants are, for example, the sorbitol or glycerol or 1,2-propylene glycol contained in the compositions according to the invention. In addition to these substances, of which at least one is present in amounts of at least 10% by weight in the compositions of the invention, suitable humectants are preferably alcohols having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof.

Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.

Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH ₂ (OH) CH ₂ OH) and other 1,2-diols such as H- (CH ₂ ) _n -CH (OH) CH ₂ OH where n = 2, 3, 4 , 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH ₂ ) _n -CH ( OH) CH ₂ CH ₂ OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 used according to the invention. The (n, n + 1) or (n, n + 2) -diols with non-terminal OH groups can also be used.

Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.

As preferred further humectants z. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.

The additional humectant (s) may be employed in the compositions of the invention in varying amounts. While depending on the rest optional ingredients amounts of a few% (for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 wt.%, Each based on the total agent) may be included, there are also formulations that significantly higher humectants -Contents have. The total moisture content (including the sorbitol, glycerol and 1,2-propylene glycols contained in the agents according to the invention) is, for example, 50, 55, 60, 65, 70, 75% by weight, in each case based on the total agent. Usual and preferred are agents according to the invention which contain (including the sorbitol, glycerol and 1,2-propylene glycols contained in the agents according to the invention) between 10 and 75% by weight of humectant. Contents between 15 and 70, preferably between 20 and 60 wt.%, In each case based on the total agent, may be preferred.

As a consistency regulator (or binder) serve z. As natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. Carboxymethylcellulose (Na-SaIz), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar, xanthan gum, succinoglycan gum, locust bean gum, pectins, water-soluble carboxyvinyl polymers (e.g., Carbopol® types), polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene glycols, in particular those having molecular weights of 1 500-1 000 000.

Other substances that are suitable for viscosity control, z. B. phyllosilicates such. As montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible to use viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.

Surface-active substances are also present in the toothpastes in support of the cleaning action and, if desired, also for the development of foam in brushing teeth and for stabilizing the polishing body dispersion in the carrier in an amount of 0.1-5% by weight.

Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque. Other suitable surfactants are Alkali metal salts, preferably sodium salts of Alkylpolyglycolethersulfat with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C ₂ - C ₁₈₎ sulfonate, esters of -CiβJ-SulfobernsteinsäuremonoalkyKC ^, of sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C ₁₂ -C ₁₆ ) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group. Also zwitterionic, ampholytic and nonionic surfactants are suitable, for. B. Oxethylates of fatty acid mono- and - diglycerides, of fatty acid sorbitan esters and alkyl (oligo) glucosides.

The oral and dental care products, especially the toothpastes, may also contain the insensitivity of the teeth-enhancing substances, such as potassium salts such. As potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate.

The compositions according to the invention, in particular the toothpastes, can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included. Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.

As a non-cationic, bactericidal component, e.g. Phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Particularly preferred antimicrobial components are halogenated diphenyl ethers, e.g. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan). They are preferably used in amounts of from 0.01 to 1% by weight in the dentifrices according to the invention. Triclosan is particularly preferably used in an amount of 0.01-0.3% by weight.

D-panthenol D - (+) - 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide exhibits a biological activity corresponding to pantothenic acid. The pantothenic acid (R - (+) - N - (2,4-dihydroxy-3,3-dimethylbutyryl-β-alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3). These substances are known to promote wound healing and have a beneficial effect on the skin, and are therefore occasionally described in toothpastes Service. The dentifrices according to the invention preferably contain 0.05-5% by weight of panthenol or a salt of pantothenic acid.

Retinol (3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin A1, but may also be used instead of retinol one of its derivatives having similar biological activity, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters is preferably used, preferably a retinol ester, in particular a fatty acid ester of a fatty acid having 12-22 carbon atoms if retinol palmitate is used, an amount of 0.001 to 0.1% by weight is preferred when using a retinol ester, for example retinol palmitate with an activity of 1.710 ⁶ IU per g When other retinol derivatives are used It is recommended to use at a concentration of 10 ³ to 10 ⁶ IU (international units) per 100 g.

Preferred dentifrices according to the present invention preferably contain, in addition to polishing agents, fluorine compounds, humectants and binders

0.01 - 1 wt .-% of a halogenated diphenyl ether

0.05 - 5 wt .-% panthenol or a salt of pantothenic acid and

0.01-0.1% by weight of a retinol ester, preferably retinol palmitate.

The agents according to the invention, in particular the toothpastes, may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as, for example, Calcium chloride, calcium acetate and dicalcium phosphate dihydrate. The concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products.

In addition to the compulsory components mentioned, the dentifrices according to the invention may contain further adjuvants and additives known per se. An additive which has been known for a long time as a toothpaste component is particularly effective in the dentifrices according to the invention: calcium glycerophosphate, the calcium salt of glycerol-1-phosphoric acid or glycerol-2-phosphoric acid or of the glycerol-1-phosphoric acid enantiomer Glycerol-3-phosphoric acid - or a mixture of these acids. The compound has one in dentifrices remineralizing effect since it provides both calcium and phosphate ions. In the dentifrices according to the invention calcium glycerophosphate is preferably used in amounts of 0.01 to 1 wt .-%. Overall, the dentifrices according to the invention may contain customary auxiliaries and additives in amounts of up to 10% by weight.

The dentifrices according to the invention may e.g. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.

As aroma oils, all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of the natural essential oils isolated from drugs and the individual components isolated therefrom.

Suitable flavors are e.g. Peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and mixtures of these components.

Suitable sweeteners are e.g. Saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose.

Further customary auxiliaries and additives for toothpastes are

Surface-active substances, preferably anionic, zwitterionic, amphoteric, nonionic surfactants or a combination of several different surfactants

Solvents and solubilizers, e.g. lower monovalent or multivalent

Alcohols or ethers, e.g. Ethanol, 1,2-propylene glycol, diethylene glycol or

Butyldi glycol

Pigments, e.g. Titanium dioxide

dyes

Buffer substances, e.g. primary, secondary or tertiary alkali metal phosphates or

Citric acid / Na citrate, other wound healing or antiinflammatory agents, e.g. allantoin,

Urea, azulene, chamomile agents, acetylsalicylic acid derivatives or rhodanide other vitamins such as ascorbic acid, biotin, tocopherol or rutin Mineral salts such as manganese, zinc or magnesium salts.

The compositions according to the invention are outstandingly suitable for tooth cleaning and care. They gently cleanse the teeth and have the added benefit of smoothing the tooth surface. For scratch value determinations (treatment of teeth under standardized conditions with different compositions and comparison of surfaces versus treatment of a standard polish), the compositions according to the invention have distinct advantages: they scratch the tooth surface significantly less than corresponding compositions containing no or less than 0.25 wt % of at least one bioactive glass and / or no or less than 10% by weight of sorbitol and / or glycerine, α / θ, π, 2r, propylene glycol. In addition, compositions containing no or less than 0.25% by weight of bioactive glass have been compared to compositions containing and containing no or less than 10% by weight of sorbitol and / or glycerol and / or 1,2-propylene glycol Compositions containing either no or less than 0.25% by weight of bioactive glass and no or less than 10% by weight of sorbitol and / or glycerol and / or 1,2-propylene glycol have been found to significantly reduce the presence of halitosis. The subjects have also agreed that the compositions of the invention compared to the comparative compositions more effectively prevent the emergence of new halitosis or that the intensity of the newly developed halitosis after a defined time at the compositions of the invention compared to the comparison compositions is significantly lower.

Further objects of the present invention are therefore the use of bioactive glasses for the smoothing of the tooth surface and the use of bioactive glasses for the prevention and / or reduction of halitosis.

As already stated, the compositions according to the invention are also distinguished by the fact that they combine a high cleaning performance with little damage to the tooth surface. Further objects of the present invention are therefore the use of bioactive glasses to prevent and / or reduce the scratching of the tooth surface and the use of bioactive glasses to reduce abrasion from the tooth surface. The use of bioactive glasses to smooth the tooth surface and / or to prevent and / or reduce halitosis and / or to prevent and / or reduce scratching of the tooth surface and / or to reduce abrasion from the tooth surface is preferably accomplished with glasses, such as described in detail above. Particularly preferred uses according to the invention are therefore characterized in that a bioactive glass is used which, based on its weight, has the following composition:

SiO ₂ 35 to 60% by weight, preferably 40 to 60% by weight,

Na ₂ OO to 35 wt .-%, preferably 5 to 30 wt .-%,

K ₂ OO to 35 wt .-%, preferably O to 20 wt .-%,

P ₂ O ₅ O to 10 wt .-%, preferably 2 to 10 wt .-%,

MgO 0 to 10% by weight, preferably 0 to 5% by weight,

CaO O to 35% by weight, preferably 5 to 30% by weight,

Al ₂ O ₃ O to 25 wt .-%, preferably 0 to 5 wt .-%,

B ₂ O ₃ O to 25 wt .-%, preferably 0 to 5 wt .-%,

TiO ₂ O to 10 wt .-%, preferably 0.1 to 5 wt .-%.

A composition according to the invention is particularly preferably used in order to achieve the stated advantages. With regard to the other ingredients of such compositions, reference is made to the above statements. Another object of the present invention is therefore the use of a composition according to the invention for smoothing the tooth surface and / or for preventing and / or reducing bad breath and / or for preventing and / or reducing the scratching of the tooth surface and / or for reducing the abrasion of the tooth surface.

With regard to preferred use concentrations, more preferably further ingredients of the respective agents used and further preferred embodiments, what is said about the agents according to the invention applies mutatis mutandis.

The following examples are intended to illustrate the subject matter of the invention without limiting it: Examples:

The following toothpastes were prepared (composition in% by weight):

A B C D

30 45 30 45 wt .-% of sorbitol (eg Neosorb 70/70 B ^®;. 70 wt .-% in water)

18 19 9 8.5 wt .-% of silica (z. B. Sident ^® 8 and / or Sident ^® 22)

2 3 2 3% by weight of polyethylene glycol MW = 1550 (eg poly wax 1550)

0.3 - 0.3 0.3 0.3 wt .-% sodium fluoride 0.8 0.8 wt = -% -. Xanthan.gum (z._B._Keltr-ol ^® _F).

0.48-0.48% by weight sodium benzoate

1 - 1 wt .-% carboxymethylcellulose (eg Cekol ^® 500 T)

1 - 1 wt .-% PEG-30 glyceryl stearate (for example Tagat S ^®).

1.5 1 1.5 1 wt .-% sodium lauryl sulfate (z. B. Texapon ^® K 1296 or Empicol ^® LXSV)

0.5 0.1 0.5 0.1 wt .-% titanium dioxide

0.2 0.2 0.2 0.2% by weight sodium saccharinate

0.1 0.1 0.1 0.1% by weight of dye solution (eg Brilliant Blue FCF, 1% by weight in water)

0.7 0.8 0.7 0.8% by weight aroma oil

1, 0 1.5 10 12 wt .-% bioactive glass * ad 100 wt .-% demineralized water

Composition:

SiO ₂ 44% by weight

Na ₂ O 23, 5% by weight

P ₂ O ₅ 5% by weight

CaO 23.5% by weight

TiO ₂ 4% by weight

The compositions A, B, C and D according to the invention are outstandingly suitable for tooth cleaning and care. They gently cleanse the teeth and have the added benefit of smoothing the tooth surface. They scratch the tooth surface significantly lower than corresponding compositions containing no bioactive glass and / or sorbitol. In addition, compositions containing no bioactive glass have been found to have a marked reduction in halitosis over compositions containing no sorbitol and compositions containing both no bioactive glass and sorbitol. The subjects have also agreed that the compositions of the invention over the

Comparative compositions prevent the emergence of new halitosis more effective or that the intensity of the newly developed halitosis after a defined time at which the compositions of the invention compared to the comparison compositions is significantly lower.

Claims

claims:

1. Oral and dental care and cleaning compositions containing c) at least 10 wt .-% sorbitol and / or glycerol and / or 1, 2-propylene glycol; d) at least 0.25% by weight of at least one bioactive glass.

2. oral and dental care and cleaning agent according to claim 1, characterized in that it is 12 to 60 wt .-%, preferably 15 to 50 wt .-%, particularly preferably 17 to 40 wt .-% and in particular 20 to 35 Wt .-% sorbitol and / or glycerol and / or 1, 2-propylene glycol.

3. Oral and dental care and cleaning agent according to one of claims 1 or 2, characterized in that it is 0.2 to 20 wt .-%, preferably 0.4 to 14% by weight, particularly preferably 0.5 to Contains 3 wt .-% and in particular 0.6 to 2 wt .-% of at least one bioactive glass.

4. Oral and dental care and cleaning agent according to one of claims 1 to 3, characterized in that the bioactive glass - based on its weight - has the following composition:

SiO ₂ 35 to 60% by weight, preferably 40 to 60% by weight,

Na ₂ O 0 to 35 wt .-%, preferably 5 to 30 wt .-%,

K ₂ O 0 to 35 wt .-%, preferably 0 to 20 wt .-%,

P ₂ O ₅ O to 10 wt .-%, preferably 2 to 10 wt .-%,

MgO 0 to 10% by weight, preferably 0 to 5% by weight,

CaO 0 to 35% by weight, preferably 5 to 30% by weight,

Al ₂ O ₃ 0 to 25 wt .-%, preferably 0 to 5 wt .-%,

B ₂ O ₃ 0 to 25 wt .-%, preferably 0 to 5 wt .-%,

TiO ₂ O to 10 wt .-%, preferably 0.1 to 5 wt .-%.

5. Oral and dental care and cleaning agent according to one of claims 1 to 4, characterized in that the antimicrobial glass particle sizes <10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns.

6. Oral and dental care and cleaning agent according to any one of claims 1 to 5, characterized in that it additionally cleaning body, preferably silicas, aluminum hydroxide, alumina, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ -2H ₂ O), sodium aluminum silicates , in particular zeolite A, organic polymers, in particular polymethacrylates or mixtures of these Reibkörper.vorzugsweise preferably in amounts of 1 to 30 wt.%, Preferably from 2.5 to 25 wt.% And in particular from 5 to 22 wt.%, each based on the entire means, contains.

7. oral and dental care and cleaning agent according to any one of claims 1 to 6, characterized in that it additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphoyphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent contains.

8. Oral and dental care and cleaning agent according to any one of claims 1 to 7, characterized in that it additionally antiplaque agents, preferably p-Hydroxybenzoesäuremethyl-, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl- Salicylic acid esters, biguanides z. As chlorhexidine, thymol, preferably in amounts of 0.1 to 5 wt.%, Preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1, 5 wt.%, Each based on the total Means containing.

9. oral and dental care and cleaning agent according to any one of claims 1 to 6, characterized in that it additionally anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate, preferably in amounts from 0.01 to 5 wt.%, Preferably from 0.1 to 2.5 wt.% And in particular from 0.2 to 1, 1 wt.%, Each based on the total agent contains.

10. Use of bioactive glasses to smooth the tooth surface.

11. Use of bioactive glasses to prevent and / or reduce halitosis.

12. Use of bioactive glasses to prevent and / or reduce the scratching of the tooth surface.

13. Use of bioactive glasses to reduce abrasion from the tooth surface.

14. Use according to one of claims 10 to 13, characterized in that a bioactive glass is used, which - based on its weight - has the following composition:

SiO ₂ 35 to 60% by weight, preferably 40 to 60% by weight,

Na ₂ O 0 to 35 wt .-%, preferably 5 to 30 wt .-%,

K ₂ O 0 to 35 wt .-%, preferably 0 to 20 wt .-%,

P ₂ O ₅ O to 10 wt .-%, preferably 2 to 10 wt .-%,

MgO 0 to 10% by weight, preferably 0 to 5% by weight,

CaO O to 35% by weight, preferably 5 to 30% by weight,

Al ₂ O ₃ O to 25 wt .-%, preferably 0 to 5 wt .-%,

B ₂ O ₃ O to 25 wt .-%, preferably 0 to 5 wt .-%,

TiO ₂ O to 10 wt .-%, preferably 0.1 to 5 wt .-%.

15. Use of a composition according to any one of claims 1 to 9 for smoothing the tooth surface and / or for preventing and / or reducing bad breath and / or for preventing and / or reducing the scratching of the tooth surface and / or for reducing the abrasion of the tooth surface ,