WO2007109288A3 - Enantiomerically pure r-etifoxine, pharmaceutical compositions thereof and methods of their use - Google Patents

Enantiomerically pure r-etifoxine, pharmaceutical compositions thereof and methods of their use Download PDF

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Publication number
WO2007109288A3
WO2007109288A3 PCT/US2007/006958 US2007006958W WO2007109288A3 WO 2007109288 A3 WO2007109288 A3 WO 2007109288A3 US 2007006958 W US2007006958 W US 2007006958W WO 2007109288 A3 WO2007109288 A3 WO 2007109288A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
etifoxine
methods
enantiomerically pure
compounds
Prior art date
Application number
PCT/US2007/006958
Other languages
French (fr)
Other versions
WO2007109288A2 (en
Inventor
David G Putman
Derk J Hogenkamp
Olivier A Dasse
Edward R Whittemore
Mark S Jensen
Original Assignee
Xytis Inc
David G Putman
Derk J Hogenkamp
Olivier A Dasse
Edward R Whittemore
Mark S Jensen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xytis Inc, David G Putman, Derk J Hogenkamp, Olivier A Dasse, Edward R Whittemore, Mark S Jensen filed Critical Xytis Inc
Publication of WO2007109288A2 publication Critical patent/WO2007109288A2/en
Publication of WO2007109288A3 publication Critical patent/WO2007109288A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Enantiomerically pure R-etifoxine and pharmaceutically acceptable salts, solvates, hydrates or prodrugs thereof are provided. Also provided are pharmaceutical compositions comprising the compounds and methods of treating disorders associated with central nervous system using the compounds and pharmaceutical compositions.
PCT/US2007/006958 2006-03-20 2007-03-20 Enantiomerically pure r-etifoxine, pharmaceutical compositions thereof and methods of their use WO2007109288A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78451406P 2006-03-20 2006-03-20
US60/784,514 2006-03-20

Publications (2)

Publication Number Publication Date
WO2007109288A2 WO2007109288A2 (en) 2007-09-27
WO2007109288A3 true WO2007109288A3 (en) 2008-04-03

Family

ID=38372325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006958 WO2007109288A2 (en) 2006-03-20 2007-03-20 Enantiomerically pure r-etifoxine, pharmaceutical compositions thereof and methods of their use

Country Status (2)

Country Link
US (1) US20080039453A1 (en)
WO (1) WO2007109288A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2930891B1 (en) * 2008-05-06 2010-09-24 Biocodex ANTI-AMNESIAN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR2937552B1 (en) * 2008-10-27 2011-05-06 Biocodex PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF ALCOHOLIC WEANING SYNDROME
WO2014181280A1 (en) * 2013-05-08 2014-11-13 Genovo Development Services Limited Stable compositions of etifoxine and its salts
FR3016881B1 (en) * 2014-01-29 2016-03-04 Biocodex TREATMENT OF DEGENERESCENCES AND PHOTO-INDUCED LESIONS OF THE RETINA
EP3151820A4 (en) 2014-06-06 2017-11-22 Flexus Biosciences, Inc. Immunoregulatory agents
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (en) 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR102537A1 (en) 2014-11-05 2017-03-08 Flexus Biosciences Inc IMMUNOMODULATING AGENTS
PT3347006T (en) * 2015-03-20 2022-10-17 Gaba Therapeutics Inc Deuterated analogs of etifoxine, their derivatives and uses therof
US10420773B2 (en) 2017-09-26 2019-09-24 Ovid Therapeutics Inc. Methods of treating developmental disorders and/or seizure disorders with etifoxine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725404A (en) * 1966-11-24 1973-04-03 Hoechst Ag 2-amino-4,4-di-substituted-4h-3,1-benzoxazines
DE3439055A1 (en) * 1984-10-25 1986-04-30 Hoechst Ag, 6230 Frankfurt Substituted 4H-3,1-benzoxazines and a medicament containing a benzodiazepine derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001052823A2 (en) * 2000-01-20 2001-07-26 Noven Pharmaceuticals, Inc. Compositions to effect the release profile in the transdermal administration of drugs
FR2888749B1 (en) * 2005-07-19 2007-10-12 Biocodex PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CEREBRAL EDEMA
FR2888748B1 (en) * 2005-07-19 2007-10-12 Biocodex NEUROPROTECTIVE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725404A (en) * 1966-11-24 1973-04-03 Hoechst Ag 2-amino-4,4-di-substituted-4h-3,1-benzoxazines
DE3439055A1 (en) * 1984-10-25 1986-04-30 Hoechst Ag, 6230 Frankfurt Substituted 4H-3,1-benzoxazines and a medicament containing a benzodiazepine derivative

Also Published As

Publication number Publication date
WO2007109288A2 (en) 2007-09-27
US20080039453A1 (en) 2008-02-14

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