WO2008070602A2 - Topical pharmaceutical composition - Google Patents
Topical pharmaceutical composition Download PDFInfo
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- WO2008070602A2 WO2008070602A2 PCT/US2007/086234 US2007086234W WO2008070602A2 WO 2008070602 A2 WO2008070602 A2 WO 2008070602A2 US 2007086234 W US2007086234 W US 2007086234W WO 2008070602 A2 WO2008070602 A2 WO 2008070602A2
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- WIPO (PCT)
- Prior art keywords
- composition
- percent
- weight
- aliphatic alcohol
- therapeutic
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- This invention relates to a novel topical pharmaceutical composition.
- this invention is a topical composition for treating cold sores.
- Herpes simplex virus (HSV-1 and HSV-2), commonly referred to as “herpes virus” or “herpes” is an infectious disease which has reached crisis proportions nationally with estimated numbers of infected people at 70%-80% of U.S. population as reported by the American Social Health Association (ASHA) and growing annually by 500,000 people or more.
- Herpes simplex virus 1 (HSV-1 )
- HSV-2 herpes simplex virus 2
- the HSV-1 virus typically causes cold sores.
- Primary HSV-1 infections frequently occur during infancy or childhood. Infection results from close contact with infected people.
- the virus can be transmitted by close personal contact, sharing personal products or by utensils.
- the resultant sores most commonly affect the lips, mouth, nose, chin or cheeks and occur shortly after exposure.
- the HSV-2 virus typically causes genital sores. Most people get HSV-2 infections following sexual contact with an infected person. Various estimates indicate that the HSV-2 virus affects between 10 and 40 million people in the United States (up to 25% of all sexually active adults in the United States) and up to 400 million people world wide.
- Herpes may enter the human body through minuscule breaks in the epidermal tissue usually by contact with an infected host and is marked by eruption of one or more vesicles, usually in groups, following an incubation period of approximately two to ten days. With either type of herpes simplex virus, a new lesion can be spread by merely touching an unaffected part of the body after touching a herpes lesion.
- Outbreaks of the herpes virus generally follow a staged progression.
- the stages are easily identifiable and include prodrome, erythema/papule, blister/vesicles, ulceration, crust and healing. Some of the stages can last less than 24 hours.
- Prodrome is generally a short period of tingling, itching, numbness or burning with no visible sign of an outbreak.
- Erythema/papule is characterized by a raised reddened area. Vesicles are the formation of one or more fluid-filled blisters, often in a cluster and usually surrounded by sore, red skin.
- the ulceration stage is when the blisters open to form painful ulcers or open sores. At the edge of the sore, a soft or hard yellow crust begins to appear.
- the vesicles can appear anywhere on epithelial tissues including the skin or mucosa, typically appearing on the lips as cold sores, on glands, oral mucosa, conjunctiva and cornea and on genitalia, anal mucosa and peri-anal tissue as herpes genitalis.
- Herpes symptoms include: inguinal swelling, pain, fever, malaise, headaches, muscle aches and swollen glands. Oral herpes may impact the trigeminal nerve, causing in some individuals excruciating facial pain, difficulty swallowing and eating and facial swelling. The sores themselves are often painful and unsightly.
- Herpes viral infections are chronic. Once the virus enters the body it lies dormant in the nerve cells and periodically reactivates. While the cause of a recurrent herpetic infection is unknown, various triggers are thought to contribute. These triggers include: exposure to sunlight; nutritional deficiencies; stress; menstruation; immunosuppression; certain foods; drugs; febrile illness; etc. When the virus reactivates, it characteristically causes a sore at the site where it first entered the body. To date, other than for Herpes Varicella-Zoster (chicken pox), there is neither a vaccine to prevent the herpes infection, nor any way to eliminate the virus from the body. Once infected, the patient has the virus for life.
- oral anti-viral medications such as acyclovir, famcyclovir, or valacyclovir
- topical anti-viral medications such as acyclovir and pencyclovir
- oral anti-viral medications such as acyclovir, famcyclovir, or valacyclovir
- topical anti-viral medications such as acyclovir and pencyclovir
- herpes can be transferred in the absence of lesions or prodromal symptoms (asymptomatic viral shedding).
- antiviral therapeutic compounds block various specific viral genetic replicative mechanisms within infected target cells. These approaches have drawbacks including toxicity to host cells, induction of drug-resistant viral substrains, and potential to act as mutagens and/or teratogens for host cells. Consequently, the search for new antiviral compounds that provide efficacious therapy, without such deleterious consequences to the host, is of paramount importance.
- n-docosanol also referred to as 1-docosanol and behenyl alcohol
- 1-docosanol and behenyl alcohol were reported to have systemic therapeutic value.
- Debar U.S. Patent No. 4,186,21 1
- 1-docosanol when taken orally was therapeutically effective in the treatment of enlargement of the prostate gland.
- Further studies disclosed in U.S. Patent No. 4,874,794 teach the use of n-docosanol as a topical antiviral agent.
- n-Docosanol is a straight chain 22-carbon saturated alcohol, which occurs naturally and is reported to have broad activity in cell cultures against lipid enveloped viruses such as herpes.
- n-Docosanol is metabolized by the cell membrane and incorporated into the cell wall where it inhibits the ability of enveloped viruses to fuse the viral envelop with the cell membrane. This fusion is critical for the viral DNA to enter the cell.
- n-docosanol is a crystalline waxy solid insoluble in water which to date has typically required composition with a non-ionic surfactant and a carrier to facilitate dermal penetration and interaction at the target cell level (see, for example, U.S. Patent No. 5,534,554, teaching a topical composition of n-docosanol having a sugar-based ester surfactant in a mineral oil carrier).
- compositions used for treating tissue affected by HSV
- compositions providing rapid relief to these ailments are still needed. It would therefore be an improvement in the art to provide compositions, systems and methods of treating tissue disorders such as those associated with HSV, in particular, cold sores related to infection with HSV-1 , that overcome the problems of the prior art.
- this invention relates to a therapeutic composition for application to the skin and membranes comprising 0.1-25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar- based ester surfactant.
- this invention relates to a therapeutic composition for application to the skin and membranes comprising 0.1-25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar-based ester surfactant, which composition forms a film over the affected area maintaining the therapeutic active in place until removed.
- a C20-C28 aliphatic alcohol in particular, n-docosanol
- a plasticizer a film-forming polymer
- a sugar-based ester surfactant which composition forms a film over the affected area maintaining the therapeutic active in place until removed.
- this invention relates to a method of treatment of recurrent herpetic episodes in humans, comprising applying a therapeutic amount of a composition for application to the skin and membranes comprising 0.1-25 percent by weight of a C20- C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar-based ester surfactant to a human in need thereof.
- a composition for application comprising 0.1-25 percent by weight of a C20- C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar-based ester surfactant to a human in need thereof.
- this invention relates to a method for reducing the pain of surface inflammation of the skin or membrane, comprising applying to an inflamed surface of the skin or membrane, a therapeutic amount of a composition comprising 0.1- 25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar-based ester surfactant.
- a composition comprising 0.1- 25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar-based ester surfactant.
- this invention relates to a method of treatment of HSV-1 in mammals, comprising applying a therapeutic amount of a composition for application to the skin and membranes comprising 0.1-25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar- based ester surfactant to a mammal in need thereof and allowing the formation of a protective film over the affected area, or an area believed to be affected by HSV-1.
- a composition for application to the skin and membranes comprising 0.1-25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar- based ester surfactant to a mammal in need thereof and allowing the formation of a protective film over the affected area, or an area believed to be affected by HSV-1.
- this invention relates to various regimens for treating, reducing the healing time and reducing the pain associated with recurrent herpetic episodes using the therapeutic composition of this invention.
- the present invention provides a topical composition and method of treatment of lesions associated with herpes viral infections of the skin, including HSV-1.
- a herpes viral outbreak generally progresses through the following stages: prodrome, erythema/papule, vesicles, ulceration, crust and healing.
- the lesion is commonly referred to as a cold sore.
- the term "lesion” as used herein at all occurrences shall refer to any of the stages of a viral outbreak.
- the terms “remove” or “removed” as used herein at all occurrences shall refer to the intentional washing off or wiping off of the inventive composition.
- treating or “treatment” as used herein at all occurrences shall refer to therapeutic therapy.
- compositions reduces the healing time of HSV-1 lesions as well as stopping the normal progression of the HSV-1 outbreak from the stage at which the initial application occurred.
- the present compositions generally reduce the healing time of an HSV-1 outbreak from approximately 10 days to about 4 to 5 days. In one embodiment of the invention, the healing time of an HSV-1 outbreak is 4 days.
- compositions of the present invention are suitable for topical applications and include, without limitation, creams, lotions, gels, ointments or pastes, and the like.
- the present compositions comprise 0.1-25 percent by weight of a C20-C28 aliphatic alcohol, in particular, n-docosanol, a plasticizer, a film-forming polymer and a sugar-based ester surfactant.
- the instant compositions are advantageous in that they are particularly suited for night time use of the composition.
- the compositions dry within 5 to 15 minutes of application. In one embodiment of the invention, the composition dries within 10 minutes of application.
- the compositions allow the therapeutic active ingredient to be in contact with the lesion for prolonged times periods until the composition is removed. Unlike other topical compositions, it does not rub off while sleeping and does not need to be reapplied during the treatment time period. In one embodiment, the composition remains on the site of application during the normal course of a night's sleep and certainly for up to eight hours.
- the composition is applied overnight for between about 6 and 10 hours. In another embodiment, the composition remains on the site of application any time of day provided the site remains substantially undisturbed.
- the inventive compositions are capable of remaining on the site of application for one or more days if undisturbed.
- the ability of the body to heal dermal wounds is a highly evolved process.
- the body stimulates and precisely regulates a host of activities that are dependent upon the environment surrounding, or within, the wound.
- the healing process occurs optimally; however, when a dermal wound is untreated, or poorly treated, the environment is not ideal and dermal healing is compromised.
- Many factors effect the wound healing environment including protection from the external environment and the amount of moisture and the level of nutrients available to the tissue.
- an occlusive film provides an ideal environment for the body to activate and maintain the healing process that prevents wound desiccation; this in turn allows easier cell migration, allows growth factors and matrix materials to be more readily available and probably maintains the temperature and electrical gradient of the wound.
- the inventive composition contains film formers that occlude or shield the wound, having beneficial wound healing properties.
- occlusive films accelerate epithelialization, alleviate pain and prevent infection.
- the film forms an occlusive barrier over the lesion providing symptomatic relief of pain, burning, itching, and tingling.
- the film-forming properties of the composition are believed to enhance the therapeutic effect of the active ingredient since it is in contact with the infected site until removed.
- the composition is easily removed once the user desires to wash it off.
- a treatment regimen for recurrent herpetic episodes would include applying the composition to the site of infection at the first sign of lesion formation, typically described as a tingling sensation, and then over the course of at least 4 days, and up to 10 days, depending upon the speed to healing of the particular outbreak.
- the composition is applied to the site of infection before sleep, allowed to dry and then removed upon awakening.
- the active therapeutic agents useful in these compositions are C20-C28 aliphatic alcohols.
- n-docosanol is the active agent.
- a suitable therapeutic dose of an active ingredient according to this invention is wherein the active agent is present in the composition in an amount between 0.1 to 25 percent by weight of the total composition. In one embodiment, the active agent is 10 percent by weight of the total composition.
- the carrier for the composition is mineral oil.
- the film-forming polymers suitable for this invention include, but are not limited to polyvinylpyrrolidone (available from ISP, New Jersey), hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and polyvinylacetate.
- the film-forming polymer is present in an amount which is between 2 and 10 percent by weight of the total composition. In one embodiment, the film-forming polymer is present in an amount which is 5.0 percent by weight of the total composition. In one embodiment of the invention, the film-forming polymer is polyvinylpyrrolidone which is present in an amount which is between 3.0 and 6.0 percent by weight of the total composition. In another embodiment of the invention, the film-forming polymer is polyvinylpyrrolidone which is present in an amount which is between 2.0 and 5.0 percent by weight of the total composition.
- the plasticizer present in the composition includes, but is not limited to glycerin (also known as glycerol).
- glycerin also known as glycerol
- the plasticizer is present in an amount which is 0.5 to 5 percent by weight of the total composition. In one embodiment the plasticizer is present in an amount which is 0.9 percent by weight of the total composition.
- an emulsifier is included and is selected from esterified sugar-based surfactants as described in U.S. Patent 5,534,554, incorporated herein by reference.
- the esterified sugar-based surfactant is sucrose stearate/distearate (available from Croda under the trade name of Crodesta F1 10).
- the emulsifier is present in an amount which is 5.0 percent by weight of the total composition.
- excipients suitably may be added to the instant composition.
- excipients include, but are not limited to, a preservative, an opacifying agent, a second therapeutic agent, and a humectant.
- a preservative may be present in the composition, which preservative includes, but is not limited to benzyl alcohol, benzoic acid, ethylenediaminetetraacetic acid (EDTA), sodium benzoate, methylparaben, propylparaben, butylparaben and sorbic acid.
- the preservative is present in an amount which is 0.05 to 5 percent by weight of the total composition.
- the preservative is benzyl alcohol and is present in an amount which is 2.7 percent by weight of the total composition.
- an opacifying agent may be present in the instant composition.
- the purpose of this agent is to provide visual confirmation that the film remains in place on the site of application.
- Suitable opacifying agents include, but are not limited to titanium dioxide, zinc oxide, stearene/acrylates and talc.
- the opacifying agent is present in an amount which is 0.2 to 5 percent by weight of the total composition.
- the opacifying agent is titanium dioxide and is present in an amount which is 1 percent by weight of the total composition.
- a further therapeutic agent may be included in the composition.
- Useful therapeutic agents for these compositions include, but are not limited to anti-viral agents such as acyclovir, famcyclovir, pencyclovir, cidofovir, foscarnet, ganciclovir, valacyclovir, and valgancyclovir.
- the further therapeutic agent is present in the composition in an amount which is 1 to 5 percent by weight of the total composition. It is recognized that in certain forms of therapy, combinations of these agents in the same delivery system may be useful in order to obtain an optimal therapeutic effect.
- a humectant may be present in the composition, which humectant includes, but is not limited to, propylene glycol, sorbitol, and glycerol triacetate (Triacetin).
- humectant is present in an amount which is 3 to 15 percent by weight of the total composition.
- the humectant is propylene glycol.
- compositions included within the scope of this invention are found in the tables below.
- Example 2 Preparation of a composition with the components found in Table 9:
- Benzyl alcohol (2.70%w/w; 16.2 mg) was added to the above mixture while the temperature was between 75-85 0 C. At this stage, the speed of the scraper blade was increased to 30% for 1 minute. The contents were seen to begin clearing, with an apparent reduction in viscosity.
- the vessel was removed from the heat source and the polyvinylpyrrolidone (5.00%w/w; 30.0 mg), glycerol (1.00 %w/w; 6.00 mg) and titanium dioxide (1.50%w/w; 9.1 mg) were added with dispersion using an impeller mixer.
- n-docosanol (10.00%w/w; 60.1 mg) and mineral oil (8.00%w/w; 48.0 mg) were combined and heated to a temperature between 75-85 0 C. Once these contents were at the required temperature, the oil phase was added to the aqueous phase while washing the oil phase vessel with the remaining water (6.18%w/w; 33.3 mg) at the same temperature.
- the scraper blade was set to 30% and the homogenizer to 20 speeds, for 3 minutes. After this, the vessel was allowed to cool to 25 0 C while allowing the homogenization to continue for an additional 3 minutes. At this point, the homogenizer was removed and the scraper blade continued to mix at 10% speed. The contents were allowed to fully cool to 25 0 C for approximately an additional 150 minutes.
- a composition according to this invention can be manufactured according to the following process.
- a separate suitable vessel transfer the purified water and turn on agitator at an appropriate speed and heat the water to between 35-85°C. Once the water is at the required temperature, turn the homogenizer to an appropriate speed and pull a vacuum. Transfer the emulsifier into this batch. After transfer, release the vacuum, and mix the batch until the emulsifier is fully dispersed. Transfer the plasticizer (and preservative and/or humectant, if used), under vacuum. Allow sufficient time for the ingredients to mix with this batch. Transfer the film- forming polymer and opacifying agent under vacuum. Release vacuum and continue mixing the aqueous batch at appropriate agitator and homogenizer speed until they are mixed homogeneously into the batch. While mixing, increase the temperature of the batch to final processing temperature between 75-85°C.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07871658.6A EP2097074A4 (en) | 2006-12-04 | 2007-12-03 | Topical pharmaceutical composition |
US12/516,879 US20100063004A1 (en) | 2006-12-04 | 2007-12-03 | Topical pharmaceutical composition |
JP2009540403A JP2010511723A (en) | 2006-12-04 | 2007-12-03 | Topical pharmaceutical composition |
CA002671615A CA2671615A1 (en) | 2006-12-04 | 2007-12-03 | Topical pharmaceutical composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86850706P | 2006-12-04 | 2006-12-04 | |
US60/868,507 | 2006-12-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008070602A2 true WO2008070602A2 (en) | 2008-06-12 |
WO2008070602A3 WO2008070602A3 (en) | 2008-09-18 |
Family
ID=39493022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/086234 WO2008070602A2 (en) | 2006-12-04 | 2007-12-03 | Topical pharmaceutical composition |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100063004A1 (en) |
EP (1) | EP2097074A4 (en) |
JP (1) | JP2010511723A (en) |
CA (1) | CA2671615A1 (en) |
WO (1) | WO2008070602A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012175879A1 (en) * | 2011-06-22 | 2012-12-27 | Laboratoires Urgo | Film-forming composition, and use thereof for treating herpes |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0808557D0 (en) | 2008-05-13 | 2008-06-18 | 3M Innovative Properties Co | Sampling devices and methods of use |
RU2736752C2 (en) * | 2013-03-15 | 2020-11-19 | Наноркс, Инк. | Metadichol-liquid and gel nano-drugs |
US10292389B2 (en) * | 2013-12-17 | 2019-05-21 | Dr. Reddy's Laboratories, S.A. | Pediculicidal composition |
EP3421044A1 (en) * | 2017-06-26 | 2019-01-02 | SastoMed GmbH | Oxygen carriers for the treatment of skin indispositions |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69523745T2 (en) * | 1994-03-21 | 2002-08-08 | Thomsen John Brown | GEL FOR TREATING SKIN DISEASES AND DISINFECTING SKIN |
US5653970A (en) * | 1994-12-08 | 1997-08-05 | Lever Brothers Company, Division Of Conopco, Inc. | Personal product compositions comprising heteroatom containing alkyl aldonamide compounds |
AUPO379596A0 (en) * | 1996-11-22 | 1996-12-19 | Soltec Research Pty Ltd | Percutaneous delivery system |
US5948822A (en) * | 1996-12-17 | 1999-09-07 | Lidak Pharmaceuticals | Treatment of hyperproliferative skin disorders with C18 to C26 alphatic alcohols |
US6645506B1 (en) * | 1997-04-18 | 2003-11-11 | Ganeden Biotech, Inc. | Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil |
US6967023B1 (en) * | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
WO2003041686A2 (en) * | 2001-11-14 | 2003-05-22 | Medlogic Global Limited | Improved therapy for topical diseases |
US20060193789A1 (en) * | 2002-10-25 | 2006-08-31 | Foamix Ltd. | Film forming foamable composition |
US20040143026A1 (en) * | 2002-12-31 | 2004-07-22 | Shah Kishore R. | Bioadhesive hydrophilic composition for treatment of mammalian skin |
US8907153B2 (en) * | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
ES2671874T3 (en) * | 2007-10-18 | 2018-06-11 | Rose U, Llc | Topical formulations of glycopyrrolate |
-
2007
- 2007-12-03 WO PCT/US2007/086234 patent/WO2008070602A2/en active Application Filing
- 2007-12-03 JP JP2009540403A patent/JP2010511723A/en active Pending
- 2007-12-03 CA CA002671615A patent/CA2671615A1/en not_active Abandoned
- 2007-12-03 US US12/516,879 patent/US20100063004A1/en not_active Abandoned
- 2007-12-03 EP EP07871658.6A patent/EP2097074A4/en not_active Withdrawn
Non-Patent Citations (1)
Title |
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See references of EP2097074A4 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012175879A1 (en) * | 2011-06-22 | 2012-12-27 | Laboratoires Urgo | Film-forming composition, and use thereof for treating herpes |
FR2976808A1 (en) * | 2011-06-22 | 2012-12-28 | Urgo Lab | FILMOGENE COMPOSITION AND USE THEREOF FOR THE TREATMENT OF HERPES |
CN103796682A (en) * | 2011-06-22 | 2014-05-14 | Urgo实验室 | Film-forming composition, and use thereof for treating herpes |
US9226989B2 (en) | 2011-06-22 | 2016-01-05 | Laboratoires Urgo | Film-forming composition, and use thereof for treating herpes |
Also Published As
Publication number | Publication date |
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EP2097074A4 (en) | 2013-05-01 |
CA2671615A1 (en) | 2008-06-12 |
WO2008070602A3 (en) | 2008-09-18 |
US20100063004A1 (en) | 2010-03-11 |
JP2010511723A (en) | 2010-04-15 |
EP2097074A2 (en) | 2009-09-09 |
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