WO2008130587A3 - Solvent-cast microneedle arrays containing active - Google Patents

Solvent-cast microneedle arrays containing active Download PDF

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Publication number
WO2008130587A3
WO2008130587A3 PCT/US2008/004943 US2008004943W WO2008130587A3 WO 2008130587 A3 WO2008130587 A3 WO 2008130587A3 US 2008004943 W US2008004943 W US 2008004943W WO 2008130587 A3 WO2008130587 A3 WO 2008130587A3
Authority
WO
WIPO (PCT)
Prior art keywords
solvent
solution
containing active
microneedle arrays
arrays containing
Prior art date
Application number
PCT/US2008/004943
Other languages
French (fr)
Other versions
WO2008130587A2 (en
Inventor
Parminder Singh
Robert Wade Worsham
Joseph C Trautman
Danir F Bayramov
Danny Lee Bowers
Andy Klemm
Steven Richard Klemm
Guohua Chen
Original Assignee
Corium Int Inc
Parminder Singh
Robert Wade Worsham
Joseph C Trautman
Danir F Bayramov
Danny Lee Bowers
Andy Klemm
Steven Richard Klemm
Guohua Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corium Int Inc, Parminder Singh, Robert Wade Worsham, Joseph C Trautman, Danir F Bayramov, Danny Lee Bowers, Andy Klemm, Steven Richard Klemm, Guohua Chen filed Critical Corium Int Inc
Priority to AU2008241470A priority Critical patent/AU2008241470B2/en
Priority to EP13163822.3A priority patent/EP2664323B1/en
Priority to CA2686093A priority patent/CA2686093C/en
Priority to EP08742989.0A priority patent/EP2146689B1/en
Priority to ES08742989T priority patent/ES2820335T3/en
Publication of WO2008130587A2 publication Critical patent/WO2008130587A2/en
Publication of WO2008130587A3 publication Critical patent/WO2008130587A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • A61K38/385Serum albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/0007Special media to be introduced, removed or treated introduced into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/07Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/30Vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00Methods of manufacture, assembly or production
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • A61M5/3298Needles arranged in parallel

Abstract

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
PCT/US2008/004943 2007-04-16 2008-04-16 Solvent-cast microneedle arrays containing active WO2008130587A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2008241470A AU2008241470B2 (en) 2007-04-16 2008-04-16 Solvent-cast microneedle arrays containing active
EP13163822.3A EP2664323B1 (en) 2007-04-16 2008-04-16 Solvent-cast microneedle arrays containing active
CA2686093A CA2686093C (en) 2007-04-16 2008-04-16 Solvent-cast microneedle arrays containing active
EP08742989.0A EP2146689B1 (en) 2007-04-16 2008-04-16 Solvent-cast microneedle arrays containing active
ES08742989T ES2820335T3 (en) 2007-04-16 2008-04-16 Solvent Cast Microneedle Arrays Containing Active Agent

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92386107P 2007-04-16 2007-04-16
US60/923,861 2007-04-16
US92526207P 2007-04-18 2007-04-18
US60/925,262 2007-04-18

Publications (2)

Publication Number Publication Date
WO2008130587A2 WO2008130587A2 (en) 2008-10-30
WO2008130587A3 true WO2008130587A3 (en) 2009-07-16

Family

ID=39587906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/004943 WO2008130587A2 (en) 2007-04-16 2008-04-16 Solvent-cast microneedle arrays containing active

Country Status (6)

Country Link
US (4) US9114238B2 (en)
EP (2) EP2664323B1 (en)
AU (1) AU2008241470B2 (en)
CA (1) CA2686093C (en)
ES (2) ES2817249T3 (en)
WO (1) WO2008130587A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107233296A (en) * 2017-05-27 2017-10-10 中山大学 Thymopeptide-5 solubility micropin and preparation method thereof

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