WO2014088520A1 - Usage of fig fruit extract and olive leaf extract combinations together with green tea and grape seed extracts - Google Patents
Usage of fig fruit extract and olive leaf extract combinations together with green tea and grape seed extracts Download PDFInfo
- Publication number
- WO2014088520A1 WO2014088520A1 PCT/TR2013/000287 TR2013000287W WO2014088520A1 WO 2014088520 A1 WO2014088520 A1 WO 2014088520A1 TR 2013000287 W TR2013000287 W TR 2013000287W WO 2014088520 A1 WO2014088520 A1 WO 2014088520A1
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- WIPO (PCT)
- Prior art keywords
- extract
- green tea
- grape seed
- olive leaf
- fruit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- the present invention is related to a herbal pharmaceutical product prepared in order to be used as a supportive product and supplement for eliminating cancer cells that have been formed and preventing the formation of cancer cells by adding green tea extracts and grape (Vitis) seed extracts to the combination of fig (Ficus carica) and olive (Olea europaea) plant combinations and the present invention is also related to the formulation of said pharmaceutical product.
- Green tea is a tea obtained from the leaves of Camellia sinensis plant. Although green tea is obtained from the same plant "Camellia Sinensis" as black tea, the only difference between them is the processing technique. The leaves of green tea undergo less process in comparison to black tea. The leaves of the green tea plant do not lose its green colour or its freshness. Black tea is subjected to oxidization whereas green tea is not subjected to oxidization and thus it is protected against the decrease of the antioxidant agents it contains. Both teas have caffeine but the caffeine rate content inside green tea is lower. Both green tea and black tea have antioxidant characteristics but the amount of antioxidant inside green tea is higher as it undergoes less process. This difference gives green tea its specific scent. More importantly it ensures the protection of polyphenols within its structure.
- Green tea provides protection against various cancer types and heart diseases.
- EGCG epigallocatechin gallate
- Green tea is considerably safe as both an extract and as tea. As the extracts did not contain caffeine they are accepted to be safer than tea. Green tea has been used for medical purposes for the past 4000 years in China. It has been used for headaches, body pains, indigestion, depression, a supportive medication for the immune system, toxin removal, and as medication that provides energy and prolongs life. In modern medicine the following characteristics have been observed: The risk of cancer is decreased (by the aid of the catechins inside green tea). Green tea prevents oesophagus cancer in men at the rate of 57% and at the rate of 60% in women. Green tea decreases the risk of prostate cancer by two thirds when it is consumed regularly.
- Green tea protects against the damage caused by ultraviolet rays that lead to skin cancer. It decreases the size of tumour. It is an antioxidant. The antioxidant inside green tea is 20 times stronger than vitamin E. It lowers cholesterol. It balances blood pressure and blood sugar. It kills bacteria. It kills influenza virus. It prevents mouth odour.
- Caffeine, flavonoids, polysaccharides, fluoride, vitamin E, EGCG (Epigallocatechin Gallate) is present in green tea.
- the effect of green tea on its own has been known for years.
- the grape seed inside the combination is known to be the strongest antioxidant as it contains vitamin e.
- the grape seed extract shows anti diabetic and antioxidant effects.
- the effects of grape seed extract on liver damages have been examined by taking into consideration aspartame trans amylase, alanine transferase and glutathione at Ankara University and it has been found out that it protects against many reasons that cause damage such as liver free radical damage.
- resveratrol which is non flavonoid
- compositions such as proanthocyanidine and catechinflavonoid
- vitamins B1,B2,C,E, potassium, phosphor sodium, sulphur, magnesium, tartaric, citric, maleic, succinic, fumaric, gliyseric, glycolic, dimethyl-succinic, and acids such as quinic acids are present inside the grape seed located within the combination.
- the ficus carica fruit (fig fruit) extract and the olive leaf extract within the combination have each been known to have antioxidant effects that strengthen the immune system for the years.
- each of the antioxidant effects of the extracts are known and are used. Although using these products separately shows antioxidant effect and although they prevent the development of cancer cells, they need to reach the therapeutic dosage in order to show the same effect. In such a case each product needs to be continually taken in high doses separately.
- Sweeteners and preservatives are added into a sufficient amount of water and the mixture is heated and cooled. All kinds of sweeteners and artificial sweeteners can be used. Liquid fig fruit extract, olive leaf extract, green tea leaf extract and grape seed extracts are added on top and are mixed. Propyleneglycole and glyserole is added to the mixture and mixed. The mixture is balanced with citric acid with a pH between 5-6. All kinds of Ph adjusters can be used as tampon materials instead of citric acid and the desired volume is completed by adding pure water. The mixture is mixed for some time and is poured into 100 or 200ml glass bottles. Preparation method (rigid gelatine capsule):
- Solid fig fruit extract, solid olive leaf extract, solid green tea leaf extract and solid grape seed extract within this combination developed for solid and liquid dosage types to be taken orally are obtained in different amounts and magnesium stearate is added and the mixture is mixed until it is homogenous.
- Other lubricants can be used instead of magnesium stearate.
- the homogenous mixture is filled into rigid gelatine capsules.
- the product can be produced in dosage forms such as soft gelatine capsules, tablets, pellets, sachets, or in solid, semi solid or liquid forms such as syrup.
- the amount of the olive leaf extract added into the mixture, the amounts of fig fruit extracts, green tea leaf extracts and grape seed extract amounts change in accordance with the active agent amounts they comprise. For this reason each extract amount may show a difference in the combination.
- the 1 unit green tea leaf extract equivalent to fig fruit extract is 0,5-1,5 units
- the extract carrying oleuropein of olive leaf could be between 1 to 5 units
- the grape seed extract can be 0,5-2 units, preferably 1 unit within the combination.
- the rate of the olive leaf extract can vary between 1-5 units in comparison to the rate of the fig fruit extract green tea leaf extract and grape seed extract and is formulated as 3 units preferably.
- liquid extracts can be used within the combination, solid extracts can also be used.
- the extract combination developed according to the present invention is used as a supportive and supplementary agent in regulating blood pressure and blood sugar, strengthening the immune system, eliminating cancer cells that have been formed and preventing the formation of new cancer cells.
Abstract
The present invention, is related to a herbal pharmaceutical product prepared in order to be used as a supportive product and supplement for eliminating cancer cells that have been formed and preventing the formation of cancer cells by adding green tea extracts and grape (Vitis) seed extracts to the combination of fig (Ficus carica) and olive (Olea europaea) plant combinations and the present invention is also related to the formulation of said pharmaceutical product.
Description
DESCRIPTION
USAGE OF FIG FRUIT EXTRACT AND OLIVE LEAF EXTRACT COMBINATIONS TOGETHER WITH GREEN TEA AND GRAPE SEED
EXTRACTS
The present invention, is related to a herbal pharmaceutical product prepared in order to be used as a supportive product and supplement for eliminating cancer cells that have been formed and preventing the formation of cancer cells by adding green tea extracts and grape (Vitis) seed extracts to the combination of fig (Ficus carica) and olive (Olea europaea) plant combinations and the present invention is also related to the formulation of said pharmaceutical product.
Green tea, is a tea obtained from the leaves of Camellia sinensis plant. Although green tea is obtained from the same plant "Camellia Sinensis" as black tea, the only difference between them is the processing technique. The leaves of green tea undergo less process in comparison to black tea. The leaves of the green tea plant do not lose its green colour or its freshness. Black tea is subjected to oxidization whereas green tea is not subjected to oxidization and thus it is protected against the decrease of the antioxidant agents it contains. Both teas have caffeine but the caffeine rate content inside green tea is lower. Both green tea and black tea have antioxidant characteristics but the amount of antioxidant inside green tea is higher as it undergoes less process. This difference gives green tea its specific scent. More importantly it ensures the protection of polyphenols within its structure. Polyphenols are strong antioxidants that are protective against cellular damages. Other important agents inside green tea are catechin, fluoride and tannins. Green tea provides protection against various cancer types and heart diseases. In a wide scaled study carried out in China, it has been found out that the rates of having diseases such as rectum, pancreas and colon cancer were lower in people who drank green tea now and then in comparison to those who did not drink green tea. The findings discovered in other various studies show that green tea could provide protection against breast, stomach and skin cancers. In a study carried out in Ohio C WR University, it has been found out that the antioxidant EGCG (epigallocatechin gallate) agent found in green tea prevents the increase l
in cancer cells. The finding that is remarkable is that EGCG does not damage normal cells. Green tea is considerably safe as both an extract and as tea. As the extracts did not contain caffeine they are accepted to be safer than tea. Green tea has been used for medical purposes for the past 4000 years in China. It has been used for headaches, body pains, indigestion, depression, a supportive medication for the immune system, toxin removal, and as medication that provides energy and prolongs life. In modern medicine the following characteristics have been observed: The risk of cancer is decreased (by the aid of the catechins inside green tea). Green tea prevents oesophagus cancer in men at the rate of 57% and at the rate of 60% in women. Green tea decreases the risk of prostate cancer by two thirds when it is consumed regularly.
Green tea protects against the damage caused by ultraviolet rays that lead to skin cancer. It decreases the size of tumour. It is an antioxidant. The antioxidant inside green tea is 20 times stronger than vitamin E. It lowers cholesterol. It balances blood pressure and blood sugar. It kills bacteria. It kills influenza virus. It prevents mouth odour.
Caffeine, flavonoids, polysaccharides, fluoride, vitamin E, EGCG (Epigallocatechin Gallate) is present in green tea. The effect of green tea on its own has been known for years. The grape seed inside the combination is known to be the strongest antioxidant as it contains vitamin e. The grape seed extract shows anti diabetic and antioxidant effects. The effects of grape seed extract on liver damages have been examined by taking into consideration aspartame trans amylase, alanine transferase and glutathione at Ankara University and it has been found out that it protects against many reasons that cause damage such as liver free radical damage.
Plenty of resveratrol which is non flavonoid, compositions such as proanthocyanidine and catechinflavonoid, vitamins B1,B2,C,E, potassium, phosphor, sodium, sulphur, magnesium, tartaric, citric, maleic, succinic, fumaric, gliyseric, glycolic, dimethyl-succinic, and acids such as quinic acids are present inside the grape seed located within the combination.
The ficus carica fruit (fig fruit) extract and the olive leaf extract within the combination have each been known to have antioxidant effects that strengthen the immune system for the years.
In the Turkish Patent application processed with the number TR 2012/04750, the usage of fig fruit extract and olive leaf extract together as antioxidants is described.
In the combination that has been improved each of the antioxidant effects of the extracts are known and are used. Although using these products separately shows antioxidant effect and although they prevent the development of cancer cells, they need to reach the therapeutic dosage in order to show the same effect. In such a case each product needs to be continually taken in high doses separately.
As it makes it easier to reach the treating dosage and as it shows a synergy effect, when ficus carica fruit (fig fruit) extract and olive leaf extract is taken together, when green tea and grape seed extract is added to this combination, the synergy effect is even more easily established and the treating dose can easily be reached.
With the combination developed according to the present invention as a result of using green tea leaves and grape seed extracts together with the fig fruit extract and olive leaf extracts a synergy effect is obtained and the therapeutic dose is easily reached. As grape seed, seeds of red grapes can be used.
Preparation method (Syrup):
Sweeteners and preservatives are added into a sufficient amount of water and the mixture is heated and cooled. All kinds of sweeteners and artificial sweeteners can be used. Liquid fig fruit extract, olive leaf extract, green tea leaf extract and grape seed extracts are added on top and are mixed. Propyleneglycole and glyserole is added to the mixture and mixed. The mixture is balanced with citric acid with a pH between 5-6. All kinds of Ph adjusters can be used as tampon materials instead of citric acid and the desired volume is completed by adding pure water. The mixture is mixed for some time and is poured into 100 or 200ml glass bottles.
Preparation method (rigid gelatine capsule):
Solid fig fruit extract, solid olive leaf extract, solid green tea leaf extract and solid grape seed extract within this combination developed for solid and liquid dosage types to be taken orally are obtained in different amounts and magnesium stearate is added and the mixture is mixed until it is homogenous. Other lubricants can be used instead of magnesium stearate.
The homogenous mixture is filled into rigid gelatine capsules. The product can be produced in dosage forms such as soft gelatine capsules, tablets, pellets, sachets, or in solid, semi solid or liquid forms such as syrup.
The amount of the olive leaf extract added into the mixture, the amounts of fig fruit extracts, green tea leaf extracts and grape seed extract amounts change in accordance with the active agent amounts they comprise. For this reason each extract amount may show a difference in the combination. The 1 unit green tea leaf extract equivalent to fig fruit extract is 0,5-1,5 units, the extract carrying oleuropein of olive leaf could be between 1 to 5 units and the grape seed extract can be 0,5-2 units, preferably 1 unit within the combination. The rate of the olive leaf extract can vary between 1-5 units in comparison to the rate of the fig fruit extract green tea leaf extract and grape seed extract and is formulated as 3 units preferably. Although liquid extracts can be used within the combination, solid extracts can also be used.
The extract combination developed according to the present invention is used as a supportive and supplementary agent in regulating blood pressure and blood sugar, strengthening the immune system, eliminating cancer cells that have been formed and preventing the formation of new cancer cells.
Claims
1. Usage of the combination of extracts obtained from the defined sections of the fig (Ficus carica) and leaf (Olea europaea) plants together with the extracts obtained from the defined sections of green tea and grape (Vitis) plants.
2. An herbal pharmaceutical combination wherein the leaf extract of green tea described in Claim 1 is used.
3. An herbal pharmaceutical combination wherein the olive leaf extract rate in comparison to the fig fruit extract, green tea extract and grape seed extract is 1 to 5 within the combination described in Claim 1 and 2.
4. A herbal pharmaceutical combination according to claim 1 ,2, and 3 wherein the rate of the olive leaf extract in comparison to fig fruit extract, green tea extract and grape seed extract is preferably 3.
5. An herbal pharmaceutical combination wherein the grape seed extract described in Claim 1 is used.
6. An herbal pharmaceutical combination according to Claim 1 ,2,3,4 and 5 indicated to be used as a supplement and supportive agent in regulating blood sugar and blood pressure, strengthening the immune system, eliminating formed cancer cells and preventing the formation of new cancer cells.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2012/13981 | 2012-12-03 | ||
| TR201213981 | 2012-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2014088520A1 true WO2014088520A1 (en) | 2014-06-12 |
Family
ID=49517613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/TR2013/000287 WO2014088520A1 (en) | 2012-12-03 | 2013-09-03 | Usage of fig fruit extract and olive leaf extract combinations together with green tea and grape seed extracts |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2014088520A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491184A (en) * | 2015-01-21 | 2015-04-08 | 通化斯威药业股份有限公司 | External used medicine capable of regulating blood pressure, reducing blood fat and softening blood vessels and preparation method |
| WO2016149424A1 (en) * | 2015-03-16 | 2016-09-22 | Nature's Sunshine Products, Inc. | Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations |
| FR3054441A1 (en) * | 2016-07-28 | 2018-02-02 | Actina | USE OF METABOLITES FROM FERMENTATION OF LACTOBACILLUS TO RESTORE THE BALANCE OF MICROBIOTE CUTANE AND INTESTINAL |
| US10702550B1 (en) | 2019-09-10 | 2020-07-07 | King Saud University | Synthesis of olive leaf extract silver nanoparticles |
| WO2022257936A1 (en) * | 2021-06-07 | 2022-12-15 | Global Preventive Medicine Biotech Company Limited | Method and composition for preventing and treating covid-19 and long covid |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007033356A2 (en) * | 2005-09-14 | 2007-03-22 | Mitsui Norin Co., Ltd | Compositions and methods for green tea catechins for modification of detoxification enzymes |
| US20070071871A1 (en) * | 2005-09-28 | 2007-03-29 | Shrikhande Anil J | Grape extract, dietary supplement thereof, and processes therefor |
| US20080254135A1 (en) * | 2007-04-10 | 2008-10-16 | Marvin Heuer | Resveratrol-containing compositions for general health and vitality |
| WO2012032494A1 (en) * | 2010-09-10 | 2012-03-15 | Behrooz Kasraee | Composition comprising a fig plant material extract and use thereof in the treatment of benign prostatic hyperplasia |
-
2013
- 2013-09-03 WO PCT/TR2013/000287 patent/WO2014088520A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007033356A2 (en) * | 2005-09-14 | 2007-03-22 | Mitsui Norin Co., Ltd | Compositions and methods for green tea catechins for modification of detoxification enzymes |
| US20070071871A1 (en) * | 2005-09-28 | 2007-03-29 | Shrikhande Anil J | Grape extract, dietary supplement thereof, and processes therefor |
| US20080254135A1 (en) * | 2007-04-10 | 2008-10-16 | Marvin Heuer | Resveratrol-containing compositions for general health and vitality |
| WO2012032494A1 (en) * | 2010-09-10 | 2012-03-15 | Behrooz Kasraee | Composition comprising a fig plant material extract and use thereof in the treatment of benign prostatic hyperplasia |
Non-Patent Citations (2)
| Title |
|---|
| BOUALLAGUI Z ET AL: "Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells", FOOD AND CHEMICAL TOXICOLOGY, PERGAMON, GB, vol. 49, no. 1, 1 January 2011 (2011-01-01), pages 179 - 184, XP027567326, ISSN: 0278-6915, [retrieved on 20101016] * |
| MCCARTY ET AL: "Targeting multiple signaling pathways as a strategy for managing prostate cancer: Multifocal signal modulation therapy", INTEGRATIVE CANCER THERAPIES, SAGE PUBLICATIONS, THOUSAND OAKS, CA, US, vol. 3, no. 4, 1 January 2004 (2004-01-01), pages 349 - 380, XP009095023, ISSN: 1534-7354, DOI: 10.1177/1534735404270757 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491184A (en) * | 2015-01-21 | 2015-04-08 | 通化斯威药业股份有限公司 | External used medicine capable of regulating blood pressure, reducing blood fat and softening blood vessels and preparation method |
| WO2016149424A1 (en) * | 2015-03-16 | 2016-09-22 | Nature's Sunshine Products, Inc. | Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations |
| JP2018510217A (en) * | 2015-03-16 | 2018-04-12 | ネイチャーズ サンシャイン プロダクツ、インク． | Phytocomplex showing multiple synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceuticals |
| US10434131B2 (en) | 2015-03-16 | 2019-10-08 | Nature's Sunshine Products, Inc. | Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations |
| US11331363B2 (en) | 2015-03-16 | 2022-05-17 | Nature's Sunshine Products, Inc. | Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations |
| FR3054441A1 (en) * | 2016-07-28 | 2018-02-02 | Actina | USE OF METABOLITES FROM FERMENTATION OF LACTOBACILLUS TO RESTORE THE BALANCE OF MICROBIOTE CUTANE AND INTESTINAL |
| US10702550B1 (en) | 2019-09-10 | 2020-07-07 | King Saud University | Synthesis of olive leaf extract silver nanoparticles |
| WO2022257936A1 (en) * | 2021-06-07 | 2022-12-15 | Global Preventive Medicine Biotech Company Limited | Method and composition for preventing and treating covid-19 and long covid |
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