WO2016133559A1 - Utilisation de lumière pour réguler des contractions utérines - Google Patents

Utilisation de lumière pour réguler des contractions utérines Download PDF

Info

Publication number
WO2016133559A1
WO2016133559A1 PCT/US2015/056904 US2015056904W WO2016133559A1 WO 2016133559 A1 WO2016133559 A1 WO 2016133559A1 US 2015056904 W US2015056904 W US 2015056904W WO 2016133559 A1 WO2016133559 A1 WO 2016133559A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
light source
eyes
pregnant human
human female
Prior art date
Application number
PCT/US2015/056904
Other languages
English (en)
Inventor
James Olcese
Original Assignee
The Florida State University Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/623,695 external-priority patent/US20150157875A1/en
Application filed by The Florida State University Research Foundation, Inc. filed Critical The Florida State University Research Foundation, Inc.
Publication of WO2016133559A1 publication Critical patent/WO2016133559A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue

Definitions

  • the invention relates to the field of pregnancy and, more particularly, to methods of regulating uterine contractions.
  • Parturition is a physiological process that occurs when pregnant females are in labor. It is characterized by increasingly frequent uterine contractions and cervical effacement, which ultimately leads to delivery of offspring. Parturition is a complex physiological and molecular biological process that has evolved differently in different species due to each species' unique environmental and temporal niches. Most mammals have adapted to selective pressures, such as the availability of food and prevalence of predators, by developing either a diurnal or nocturnal activity phase. Pregnant females have adapted to deliver their offspring in their den or home camp rather than in the field, which enhances their safety, security, and birth success.
  • Melatonin plays a role in stimulating uterine contractions. Exposing pregnant females to light during nocturnal hours decreases their endogenous melatonin levels, which regulates nocturnal uterine contractions. The various method aspects of the invention take advantage of this phenomenon.
  • a method of regulating uterine contractions comprises suppressing a nocturnal endogenous melatonin level of a pregnant female experiencing uterine contractions by exposing the pregnant female during nighttime to a light source emitting visible light.
  • a method of regulating uterine contractions in a pregnant female comprises selecting a pregnant female experiencing uterine contractions, directing light from a light source emitting visible light onto the pregnant females eyes at night, the intensity of the visible light being sufficient to suppress the pregnant female's endogenous melatonin level.
  • a method of regulating nocturnal uterine contractions during preterm labor comprises exposing a pregnant female experiencing preterm labor to a light source at night, the light source emitting visible light effective to suppress the pregnant female's endogenous melatonin level.
  • an eyeglass headset comprises a body configured to be worn by a late term pregnant female.
  • a light source is carried by the body and configured to direct light into the eyes of the late term pregnant human female to reduce uterine contractions occurring at night in the late term pregnant human female and suppress the regular nocturnal endogenous melatonin secretions of the late-term pregnant human female experiencing uterine contractions.
  • the light source is configured to direct into the eyes of the pregnant human female during the night light having a wavelength of about 450 to 570 nm and an irradiance of about 0.1 to 0.5 W/m 2 . In another example, it may have an intensity of about 1 ,000 to 10,000 lux, in a non-iimiting example.
  • the light source may comprise a light source carried by the body for each of the eyes.
  • the light source may be timed for exposure between 9 p.m. and 6 a.m.
  • the light source may be configured to direct light intermittently into the eyes of the pregnant human female during the night.
  • the light source may be configured to direct light having a wavelength of 450 to 500 nm into the eyes of the pregnant human female.
  • the controller may be connected to the light source and configured to control at least one of the irradiance, wavelength and intensity of light emitted from the light source.
  • the controlier may include a processor and a memory coupled thereto and configured to store instructions regarding at least one of the duration, wavelength and irradiance of light emitted from the light source.
  • the controller may be configured to direct light intermittently over a period of time at night into the eyes and at a wavelength sufficient to shift the biologic time clock of the human female. In an example, this wavelength may correspond to visible light.
  • a method of reducing uterine contractions occurring at night in a late-term pregnant human female includes suppressing the regular nocturnal endogenous melatonin secretions of the late-term pregnant human female experiencing uterine contractions by directing into the eyes of the pregnant human female during the night light from a light source having a wavelength of about 450 to 570 nm and an irradiance of about 0.1 to 0.5 W/m 2 . In another example, it may have an intensity of about 1 ,000 to 10,000 lux.
  • a method of reducing uterine contractions occurring in a late-term pregnant human female visiting a facility that treats pregnant human females includes suppressing the regular endogenous melatonin secretions of the late-term pregnant human female experiencing uterine contractions within the facility by directing into the eyes of the pregnant human female ambient light from a light source having a wavelength of about 450 to 570 nm.
  • the facility includes at least one of a waiting room, delivery room, and treatment room for pregnant human females and the light source is positioned in the at least one of the waiting room, delivery room, and treatment room and configured to direct the ambient light into the eyes of the late-term pregnant female while the female is in the at least one of the waiting room, delivery room, and treatment room.
  • a system for reducing uterine contractions occurring in a late- term pregnant human female visiting a facility that treats pregnant human females.
  • a light source is positioned within the facility, and a controller is connected to the light source and configured to control the light source to direct ambient light into the eyes of the late term pregnant human female for reducing uterine contractions occurring in the !ate term pregnant human female and suppressing the regular endogenous melatonin secretions of the late-term pregnant human female experiencing uterine contractions.
  • the controller is configured to control the light source to direct into the eyes of the pregnant human female during the night light having a wavelength of about 450 to 570 nm.
  • FIG. 1 is a bar graph showing the number of contractions per hour a pregnant volunteer experienced overnight and how the number changed when a lamp was turned on for about one hour.
  • FIG. 2 is a bar graph showing the number of contractions per hour another pregnant volunteer experienced overnight and how the number changed when a lamp was turned on for about one hour.
  • FIG. 3 is a line graph showing composite results of the melatonin level of five pregnant volunteers when a lamp was turned on for about an hour.
  • FIG. 4 is a fragmentary, perspective view of an eyeglass headset in accordance with a non-iimiting example.
  • FIG. 5 is a block diagram of the components used in the eyeglass headset shown in FIG. 4 in accordance with a non-limiting example.
  • FIG. 6 is a fragmentary, plan view of a system for use in a facility that treats pregnant human females in accordance with a non-limiting example.
  • the various method aspects of the invention are directed to regulating uterine contractions by exposing pregnant females to light.
  • regulating in this context means reducing the number of uterine contractions over a given time period, reducing the intensity of the uterine contractions, and or preventing uterine contractions from occurring when they might otherwise occur in the absence of light. These methods are useful, for example, to prolong pregnancy, prevent preterm birth, or, if preterm birth is inevitable, to delay the preterm birth.
  • endogenous melatonin level gradually decreases until morning and remains very low throughout the day. The cycle then repeats itself the foilowing night. Because the endogenous melatonin level reaches its peak at night, this is the time period during which melatonin stimulates the most contractions. By exposing a pregnant female to a light source with sufficient intensity to suppress the endogenous melatonin level, uterine contractions are suppressed.
  • pressing the endogenous melatonin level refers to either reducing the endogenous melatonin level from normal or preventing the endogenous melatonin level from rising as it normally would at night.
  • a method of regulating uterine contractions involves suppressing the nocturnal endogenous melatonin level of a pregnant femate experiencing uterine contractions by exposing the pregnant female during nighttime to a light source emitting visible light.
  • a method of regulating uterine contractions in a pregnant female involves selecting a pregnant female experiencing uterine contractions and directing light from a light source emitting visible light onto the pregnant female's eyes at night. The intensity of the visible light is sufficient to suppress the pregnant female's endogenous melatonin level.
  • a method of regulating nocturnal uterine contractions during preterm labor involves exposing a pregnant female experiencing preterm labor to a light source at night, where the light source emits visible light effective to suppress the pregnant female's endogenous melatonin level.
  • the light source must be of sufficient intensity and color to be able to suppress the endogenous melatonin level.
  • the light source was a full spectrum 10,000 lux phototherapy lamp positioned about 1 meter from the pregnant female's eyes. Although this yielded good results, other light sources are suitable for use in the methods.
  • a suitable intensity range for the light source is about 1 ,000 to about 10,000 lux.
  • the light source spectrum may be tuned to optimize the amount of melatonin suppression.
  • One preferred light source predominantly emits blue light. Blue light in the wavelength range of about 450 to about 500 nm is particularly preferred.
  • the pregnant female is exposed to the light during typical nocturnal or nighttime hours, preferably between about 9 p.m. to about 6 a.m.
  • the pregnant female may be exposed to the light source continuously throughout the night or in smaller time increments during the night.
  • the light source is a headset or set of goggles.
  • the headset includes a body attached to the wearer's head for supporting a first light over the pregnant female's left eye and a second Sight over the pregnant female's right eye.
  • the light source is adapted to emit light in discrete on/off cycles or pulses.
  • the duration of the pulses and the separation between successive pulses is adjusted to obtain the desired amount of endogenous melatonin suppression.
  • FIGS. 1-3 show the results of these experiments.
  • FIGS. 1 and 2 show the number of contractions two different women experienced per hour.
  • FIG. 3 shows the composite results of the melatonin levels of the women studied.
  • the arrow in each graph represents the time at which the lamp was turned on.
  • FIG. 3 shows that the women's
  • an eyeglass headset 100 in accordance with a non-limiting example, which is formed similar to goggles or glasses that cover the eyes and limit ambient light.
  • the body 102 of the eyeglass headset 100 is configured to be worn by the user, in this example a late-term pregnant female.
  • a light source is carried by the body 102, and in this example, light sources 104a, 106a are carried by the body to divert light into each of the eyes as illustrated.
  • the light sources 104a, 106a are configured to direct light into the eyes of the late-term pregnant human female to reduce uterine contractions occurring at night in the fate-term pregnant human female and suppress the regular nocturnal endogenous melatonin secretions of the late-term pregnant human female experiencing uterine contractions.
  • the light sources 104a, 106a in an example are configured to direct into the eyes of the pregnant human female during the night light having a wavelength of about 450 to 570 nm and at an irradiance of 0.1 to 0.5 W/m 2 . This wavelength range encompasses the preferred blue and into the green color. As noted before, it may include a light intensity of 1,000 to 10,000 lux in an example.
  • the body 102 includes typical component parts of an eyeglass frame, but designed in this example to fit onto the wearer and limit ambient normal light from entering the eyes of the wearer. Normal light is typically 400 to 700 nm.
  • the body 102 includes an enlarged and flattened top bar 120, which in this example is integral with the bridge 122 and nose pad area 124.
  • the rim 126 is also enlarged as illustrated and extends inward and forms a substantially planar mounting surface 128 where
  • the temple 132 is enlarged more than normal as compared to more typical eyeglasses to support the greater body 102 dimensions.
  • Each temple 132 may be pivotabiy mounted to the enlarged rim 126 so the headset, i.e., glasses, may fold and be more compact for storage.
  • Ail component parts may be formed of lightweight materia!, such as injection molded plastic.
  • a sensor array 140 is carried along the rear edge 132 of the top bar 120 and positioned to engage the forehead of the wearer, which typically may be a late-term pregnant female.
  • the use of the eyeglass headset 100 is not limited to later-term pregnant females and other wearers may use the eyeglass headset to take advantage of the sensor array 140 and other functions, such as use of emitted light to aid in shifting the biological time clock of the wearer.
  • the eyeglass headset 100 may be used by others in long distance air flights or other situations where jet lag could be problematic as explained below.
  • a portable wireless device 150 is illustrated, for example a cell phone, and wireless power device 54 that interoperate with the eyeglass headset 100 as will be explained below.
  • the sensor array 140 may include individual sensors for determining different body functions, including EEG, EMG, EOG, temperature, body movement or use as an oximeter for blood oxygen sensing. Other sensors may be included. These sensors interoperate with the controller 130 and may be wired or wireless.
  • green light may also be effective to decrease endogenous melatonin levels and in regulating or reducing uterine contractions.
  • Green light has a wavelength of about 495 or 500 to 570 nm and a frequency of about 575 to 525 THz. Green light is between the blue and yellow in the spectrum of visible light. Although the green light may not be as effective as the blue light, it still may be used.
  • the light source 104a, 106a for each eye may be timed for exposure between 9:00 p.m. and 6:00 a.m. and may be configured to direct light intermittently into the eyes of the pregnant human female during the night.
  • the blue light of 450 to 500 nm or 450 to 490 nm is preferred to be directed into the eyes of the pregnant human female.
  • the controller 130 is carried by the body 102, and in the example shown in FIG. 4, carried at the mounting surface 28, but can be carried at other areas forming the body 102, including the temple 132 or enlarged top bar 120. As shown in FIG. 5, the controller 130 includes a processor 160 and memory 162. The controller 130 is connected to each of the light sources 104a, 106a by either wired or wireless
  • An example light source is a LED or multiple LED's for each light source that can be controlled in terms of its on/off time such as intermittent on/off operation and have its wavelength and intensity changed to allow a range of wavelengths such as visible light, blue light, green light, or any combination.
  • the controller 130 includes the processor 162 and a memory 164 coupled thereto and configured to store instructions regarding the operation of the sensor array 140, for example, or configure the light sources 104a, 106a so that the time, wavelength and irradiance of light emitted from the light sources can be controlled. Intensity may be controlled.
  • the processor 162 and memory 164 interoperate with a RF transceiver 166 that may send and receive different instructions and data.
  • the RF transceiver 166 may send instructions to one of the light sources 104a, 106a to change its operation as to intermittent flashing, duration, intensity and/or wavelength. This can be accomplished in one example using an RF module 104b, 106b, processor 104c, 106c, and memory 104d, 106d having stored instructions and configuring each light source 104a, 106a.
  • Each light source 104a, 106a may include a wireless power module 104e, 106e and be operable with a wireless power inductor module 168 at the controller 130 and receive inductive power from the wireless power source 150.
  • a battery 170 couid be used at the controller 130 instead.
  • the sensor array 140 may also include a processor 174, memory 176, and RF module 178 and interoperate with the controller 130. It may also include wireless power module 180 or a battery, it should be understood that each light source 104a, 106a may be formed from one or more light emitting devices, such as light emitting diodes, which may be controlled so that not only wavelength, but irradiance of emitted light may be controlled. Intensity may be controlled. If multiple light emitting devices are used, the combination and range of wavelength and irradiance and/or intensity could be varied for specific persons.
  • Each iight source 104a, 106a could be formed from an array of LED's, each having a range of wavelengths of variable intensity or irradiance.
  • the controller 130 may be configured to direct Iight intermittently over a period of time at night into the eyes and at a wavelength sufficient to shift the biologic time clock of the human female.
  • the light sources 104a, 106a may be configured to have a wavelength in the range of 400 to 700 nm corresponding to visible iight.
  • the different intermittent operation or phases of Iight can be timed to phase-shift the biological time clock of the wearer.
  • the Iight irradiance is between about 0.1 and 0.5 W/m 2 for b!ue/green or blue light. It is possible to use a wireless power inductor module 168.
  • the processor 162 and RF transceiver 166, the light sources 104a, 106a and other components may receive wireless power transmitted from the wireless power source 150 that is external in this example or even part of the controller.
  • a battery 170 may be used to power the different components.
  • the sensor array 140, the light sources 104a, 106a, or other components may each include batteries.
  • the illumination of light may be increased over a predetermined period of time and increased over a time period of between about 5 to 30 seconds.
  • the light may be pulsed in discrete on and off cycles, and in an example, is pulsed for about 1-3 seconds per minute for about 30 to about 60 minutes.
  • the light source is formed as a light emitting diode or series of light emitting diodes at each light source.
  • controller 130 It is possible to program the controller 130 from the wireless mobile device 154 and communicate for programming, data recording and record keeping as illustrated in FIG. 5.
  • the mobile wireless device 154 may be used to program the processor 162 in the controller 130 with a special application program that could be downloaded on the device as an example.
  • the processor 162 is programmed so that the illumination of the light sources 104a, 106a is increased over a time period of between about 5 to 30 seconds.
  • the fight may be pulsed in discrete on and off cycles such as between 1 to 3 seconds per minute for about 30 to about 60 minutes as noted before.
  • the duration, wavelength and trradiance of light may be controlled and instructions stored in the memory of the controller or light source. Intensity may be controlled.
  • the processor 162 as part of the controller 130 may direct the light sources 104a, 106a to emit pulses at certain times of the night for a predetermined length of time.
  • the processor 162 can be user programmable via the separate wireless device 154 or preprogrammed when purchased by a user.
  • a mobile wireless device 154 such as a cellular phone, iPhone or other wireless devices may be used as a controller 130 in one example to transmit information to the processor 162 via the RF transceiver 166 or even directly to the sensor array 140 via its RF module 178 or directly to the light sources 104a, 106a, for alternate timing and light intensity profiles and sensor configurations.
  • White light may not be feasible especially with a partner sleeping near the user and it could be bothersome to the user.
  • the blue light is the better light and just as effective or more effective as white light and has been found effective to suppress melatonin and overtones with green light may be used.
  • white light may not penetrate the eyelids as well as the blue light does.
  • the cycling can range from zero power up to full power in ten seconds as an example and can remain on for a minute or half a minute and then go off again through the night.
  • the eyeglass headset 100 It is possible to operate the eyeglass headset 100 with a phase response curve to shift the clock eastward or westward by a predetermined number of hours depending on when the light is given. If the light is given in the early evening hours, then time is truncated opposite from light given in the early morning to truncate for the natural low point. It is possible to accelerate the clock. In one example, light pulses are given in the evening and morning for one-half hour to one hour each time and with intermittent ramping and intermittent operation to reduce the truncation. These times can vary.
  • inductive coupling uses magnetic fields that are a natural part of the current movement through a wire.
  • the electrical current moves through a wire, it creates a circular magnetic field around the wire and bends the wire into a coil that amplifies the magnetic field. The more loops the coil has, the larger the field will be produced.
  • the field can include a current in the wire.
  • resonance and wireless power conduction can take place differently when the electromagnetic fields around the coils resonate at the same frequency.
  • the inductor can be formed as a curved coil of wire and a capacitance plate can hold a charge and attach to each end of the coil.
  • a capacitance plate can hold a charge and attach to each end of the coil.
  • the electricity can tunnel from one coil to the other as it travels along the electromagnetic wave if both have the same resonant frequency.
  • Electromagnetic induction is proportional to the intensity of the current and voltage in the conductor, which produces the fields and to the frequency. Other wireless power techniques may be used.
  • the controller 130 can control the light emissions to allow an artificial dawn or wake-up by light only such as by being timed to certain portions of the night or for napping as noted before.
  • the controller 130 may control timed stages of sleep for short or long power naps or even into a deep sleep for better body and mind renewal over a day or night.
  • the sensor array 140 has various sensors as noted before.
  • An example is an EMG sensor 190 to measure EMG (electromyogram) for muscle activity, including different twitches and movements of the face and even teeth grinding that occur during sleep. This can aid in determining if there is proper REM sleep.
  • An EEG sensor 192 could measure the EEG (electroencephalography) for brain waves and determine different sleep stages. It is possible to include an oximetry sensor 194 to determine a pulse rate and blood oxygen levels. Different sensors could be used, including two sensors or electrodes that emit two different wavelengths such as red and near-infrared and measure the change in light absorbance at each wavelength.
  • oxygenated hemoglobin For example, more infrared light is absorbed by oxygenated hemoglobin, which allows the red light to pass through. Any deoxygenated hemoglobin will absorb more red light, but allow the infrared light to pass through.
  • the blood oxygen levels and heart rate may thus be determined.
  • EMG signals may be emitted at a higher frequency than any EEG signals to determine the differences and prevent signal interference.
  • the controller 130 may use different processing techniques to distinguish among EMG-artifacts and EEG signals. Pulse oximetry measurements can be used to diagnose for sleep apnea. Different oximeter sensors may be used, including reflectance-based sensors. Dry electrodes may be used that incorporate micro-needles to penetrate layers of the skin. MEMS technology may be used in conjunction with the electrodes. Different processing techniques, including semiconductor processing techniques, may be used to form different electrodes, including dry electrodes.
  • FIG. 6 is a fragmentary plan view of a facility 210 as a pregnancy clinic forming a system, in accordance with a non-limiting example, that may reduce uterine contractions occurring in a late-term pregnant human female when that female visits the facility.
  • a facility 210 as a pregnancy clinic forming a system, in accordance with a non-limiting example, that may reduce uterine contractions occurring in a late-term pregnant human female when that female visits the facility.
  • different areas of the facility such as the delivery room 212, waiting room area 214, or examination room 216 may each contain a light source 2 8.
  • a controller 220 may be connected to the light source 218 and configured to control the light source to direct ambient light into the eyes of the late-term pregnant human female for reducing uterine contractions in the late-term pregnant human female and
  • the controller 220 is shown incorporating a processor 222, memory 224, and RF module 226 in one of the offices and is configured to control the light source 2 8 to direct into the eyes of the pregnant human female the ambient light having a wavelength of about 450 to 570 nm, and in an example, having an intensity of about 1 ,000 to 10,000 lux or light irradiance of about 0.1 to 0.5 W/m 2 .
  • Wireless RF or wired connections from the controller 220 to light sources 218 may be used.
  • the wider range of ambient light is disclosed, it is possible to use the blue ambient light having a wavelength of about 450 to 500 nm or 450 to 490 nm.
  • the delivery room 212, watting room 214, and the three examination rooms 216 each would have a light source 218 to direct the ambient light into the eyes of the pregnant human female and preferably at a wavelength of about 450 to 570 nm, and in an example, the blue wavelength of about 450 to 500 nm.
  • the lobby 230 and other offices 232 could include a light source that emits the ambient light to operate and reduce uterine contractions.
  • a light source that emits the ambient light to operate and reduce uterine contractions.
  • Glattre E Bjerkedal T. The 24-hour rhythmicity of birth: a population study. Acta Obstet Gynecol Scand. 1983; 62:31-36.

Abstract

L'invention concerne une monture de lunettes comprenant un corps destiné à être porté par une femme enceinte à grossesse prolongée. Ladite invention comprend une source de lumière portée par le corps qui dirige la lumière dans les yeux de la femme enceinte à grossesse prolongée pour réduire des contractions utérines se produisant la nuit chez la femme à grossesse prolongée et supprimer les sécrétions de mélatonine endogène nocturnes régulières de la femme enceinte à grossesse prolongée subissant des contractions utérines. La source de lumière dirige, dans les yeux de la femme enceinte, de façon intermittente pendant la nuit, une lumière bleue ayant une longueur d'onde d'environ 450 à 570 nm.
PCT/US2015/056904 2015-02-17 2015-10-22 Utilisation de lumière pour réguler des contractions utérines WO2016133559A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/623,695 US20150157875A1 (en) 2007-12-03 2015-02-17 Using light to regulate uterine contractions
US14/623,695 2015-02-17

Publications (1)

Publication Number Publication Date
WO2016133559A1 true WO2016133559A1 (fr) 2016-08-25

Family

ID=56739124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/056904 WO2016133559A1 (fr) 2015-02-17 2015-10-22 Utilisation de lumière pour réguler des contractions utérines

Country Status (1)

Country Link
WO (1) WO2016133559A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3657909A1 (fr) * 2018-11-21 2020-05-27 BrainLit AB Dispositif électronique pouvant être porté sur la tête

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090201462A1 (en) * 2008-02-07 2009-08-13 Jake Gruber Retinal melatonin suppressor
US20130060306A1 (en) * 2010-05-14 2013-03-07 Michael Edward Colbauch Efficient circadian and related system modulation with a sleep mask
US20140094877A1 (en) * 2007-12-03 2014-04-03 The Florida State University Research Foundation, Inc Using light to regulate uterine contractions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140094877A1 (en) * 2007-12-03 2014-04-03 The Florida State University Research Foundation, Inc Using light to regulate uterine contractions
US20090201462A1 (en) * 2008-02-07 2009-08-13 Jake Gruber Retinal melatonin suppressor
US20130060306A1 (en) * 2010-05-14 2013-03-07 Michael Edward Colbauch Efficient circadian and related system modulation with a sleep mask

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DUCSAY ET AL.: "Photoperiod Regulation of Uterine Activity and Melatonin Rhythms in the Pregnant Rhesus Macaque.", BIOLOGY OF REPRODUCTION, vol. 44, no. 6, 1 June 1991 (1991-06-01), pages 967 - 974, Retrieved from the Internet <URL:hftp://www.biolreprod.org/content/44/6/967.full.pdf+html> [retrieved on 20151217] *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3657909A1 (fr) * 2018-11-21 2020-05-27 BrainLit AB Dispositif électronique pouvant être porté sur la tête
WO2020104096A1 (fr) * 2018-11-21 2020-05-28 Brainlit Ab Dispositif électronique porté sur la tête
CN113168034A (zh) * 2018-11-21 2021-07-23 布莱茵力特有限公司 头戴式电子设备
US11617897B2 (en) 2018-11-21 2023-04-04 Brainlit Ab Head worn electronic device

Similar Documents

Publication Publication Date Title
CA2966774C (fr) Masque de sommeil qui comprend un eclairage pour reguler les contractions uterines
EP3024546B1 (fr) Système pour fournir une luminothérapie et modifier le rythme circadien
EP2670481B1 (fr) Lunettes de luminothérapie
AU2020325024B2 (en) Treatment of central nervous system disorders
US20120197358A1 (en) Light Therapy for Treating or Managing Diabetes and Metabolic Syndrome
US20160158487A1 (en) System and method for providing light therapy and modifying circadian rhythm
JP2012528648A (ja) リアルタイムのｅｅｇ読み取りを用いた光線療法の用量設定
US20080170476A1 (en) Suprachiasmatic Nucleus Inducing, Melatonin Suppressing Light Emitting Device to Enhance Wake Cycle
US20130119886A1 (en) Suprachiasmatic Nucleus Inducing, Melatonin Suppressing Light Emitting Device to Enhance Wake Cycle
US20140012353A1 (en) Light Therapy for Increasing CD34+ Cell Count in Peripheral Blood
KR20150123829A (ko) 의료 장치, 시스템 및 방법
WO2014128193A1 (fr) Dispositif d&#39;éclairage portatif permettant de manipuler l&#39;horloge circadienne d&#39;un sujet
WO2019153968A1 (fr) Procédé et appareil pour configurer et réguler des paramètres d&#39;émission de lumière d&#39;un appareil d&#39;éclairage de rythme biologique
US10118050B2 (en) Using light to regulate uterine contractions
WO2019153966A1 (fr) Appareil d&#39;éclairage pour réguler les rythmes biologiques humains
KR20090109651A (ko) 레이저 조사 수단을 가진 헤드폰
WO2016133559A1 (fr) Utilisation de lumière pour réguler des contractions utérines
WO2013072701A1 (fr) Dispositif, programme et procédé de traitement par rayonnement lumineux
RU2758549C1 (ru) Стимуляция выброса окситоцина
CN211486269U (zh) 一种心脏术后多源康复训练带
WO2017076320A1 (fr) Procédé et appareil mettant en oeuvre un champ électromagnétique pour moduler des régions du cerveau chargées de l&#39;excitation et du sommeil
CN115501444A (zh) 一种光助眠及唤醒式闹钟及其唤醒方法
KR200292054Y1 (ko) 이엘 시트의 색과 빛 및 주파수의 회절을 이용한 치료장치
RO130307A0 (ro) Dispozitiv vibraţional de stimulare
WO2014089248A1 (fr) Luminothérapie pour augmenter le compte de cellules cd34+ dans le sang périphérique

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15882880

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15882880

Country of ref document: EP

Kind code of ref document: A1